5F5G

Structure of E.Coli GlpG Y205F mutant complexed with peptidic inhibitor Ac-RMA-CHO in the DMPC/CHAPSO bicelle

Summary for 5F5G

• Entry DOI: 10.2210/pdb5f5g/pdb
• Related: 5F5B 5F5D 5F5J 5F5K
• Descriptor: Rhomboid protease GlpG, ACE-ARG-MET-ALA-aldehyde (3 entities in total)
• Functional Keywords: glpg, rhomboid, intramembrane protease, bicelle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Escherichia coli; More
• Cellular location: Cell inner membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein : A0A0J2E248
• Total number of polymer chains: 2
• Total formula weight: 24187.65

Authors

Urban, S.,Cho, S.,Dickey, S.W. (deposition date: 2015-12-04, release date: 2016-04-06)

• Primary citation: Cho, S.,Dickey, S.W.,Urban, S.; Crystal Structures and Inhibition Kinetics Reveal a Two-Stage Catalytic Mechanism with Drug Design Implications for Rhomboid Proteolysis.; Mol.Cell, 61:329-340, 2016; PubMed: 26805573; DOI: 10.1016/j.molcel.2015.12.022

Experimental method

X-RAY DIFFRACTION (2.3 Å)