2YTC
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![BU of 2ytc by Molmil](/molmil-images/mine/2ytc) | Solution structure of RNA binding domain in Pre-mRNA-splicing factor RBM22 | Descriptor: | Pre-mRNA-splicing factor RBM22 | Authors: | Kasahara, N, Tsuda, K, Muto, Y, Inoue, M, Kigawa, T, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-04-05 | Release date: | 2007-10-09 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of RNA binding domain in Pre-mRNA-splicing factor RBM22 To be Published
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5XJC
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![BU of 5xjc by Molmil](/molmil-images/mine/5xjc) | Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhang, X, Yan, C, Hang, J, Finci, I.L, Lei, J, Shi, Y. | Deposit date: | 2017-04-30 | Release date: | 2017-07-05 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | An Atomic Structure of the Human Spliceosome Cell, 169, 2017
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7QTT
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![BU of 7qtt by Molmil](/molmil-images/mine/7qtt) | |
6QDV
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![BU of 6qdv by Molmil](/molmil-images/mine/6qdv) | Human post-catalytic P complex spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Fica, S.M, Oubridge, C, Wilkinson, M.E, Newman, A.J, Nagai, K. | Deposit date: | 2019-01-03 | Release date: | 2019-02-20 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science, 363, 2019
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9FMD
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![BU of 9fmd by Molmil](/molmil-images/mine/9fmd) | |
5MQF
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![BU of 5mqf by Molmil](/molmil-images/mine/5mqf) | Cryo-EM structure of a human spliceosome activated for step 2 of splicing (C* complex) | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ATP-dependent RNA helicase DHX8, Cell division cycle 5-like protein, ... | Authors: | Bertram, K, Hartmuth, K, Kastner, B. | Deposit date: | 2016-12-20 | Release date: | 2017-03-22 | Last modified: | 2018-11-21 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature, 542, 2017
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6FF4
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![BU of 6ff4 by Molmil](/molmil-images/mine/6ff4) | human Bact spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. | Deposit date: | 2018-01-03 | Release date: | 2018-08-29 | Last modified: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and Conformational Dynamics of the Human Spliceosomal BactComplex. Cell, 172, 2018
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6ID0
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![BU of 6id0 by Molmil](/molmil-images/mine/6id0) | Cryo-EM structure of a human intron lariat spliceosome prior to Prp43 loaded (ILS1 complex) at 2.9 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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6ID1
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![BU of 6id1 by Molmil](/molmil-images/mine/6id1) | Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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6ICZ
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![BU of 6icz by Molmil](/molmil-images/mine/6icz) | Cryo-EM structure of a human post-catalytic spliceosome (P complex) at 3.0 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
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8CH6
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![BU of 8ch6 by Molmil](/molmil-images/mine/8ch6) | Structure of a late-stage activated spliceosome (BAqr) arrested with a dominant-negative Aquarius mutant (state B complex). | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Cretu, C, Schmitzova, J, Pena, V. | Deposit date: | 2023-02-07 | Release date: | 2023-05-10 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural basis of catalytic activation in human splicing. Nature, 617, 2023
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8C6J
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![BU of 8c6j by Molmil](/molmil-images/mine/8c6j) | Human spliceosomal PM5 C* complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Dybkov, O, Kastner, B, Luehrmann, R. | Deposit date: | 2023-01-12 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Regulation of 3' splice site selection after step 1 of splicing by spliceosomal C* proteins. Sci Adv, 9, 2023
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6FF7
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![BU of 6ff7 by Molmil](/molmil-images/mine/6ff7) | human Bact spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, BUD13 homolog, ... | Authors: | Haselbach, D, Komarov, I, Agafonov, D, Hartmuth, K, Graf, B, Kastner, B, Luehrmann, R, Stark, H. | Deposit date: | 2018-01-03 | Release date: | 2019-03-13 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure and Conformational Dynamics of the Human Spliceosomal BactComplex. Cell, 172, 2018
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5YZG
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![BU of 5yzg by Molmil](/molmil-images/mine/5yzg) | The Cryo-EM Structure of Human Catalytic Step I Spliceosome (C complex) at 4.1 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Zhan, X, Yan, C, Zhang, X, Lei, J, Shi, Y. | Deposit date: | 2017-12-14 | Release date: | 2018-08-08 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of a human catalytic step I spliceosome Science, 359, 2018
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5Z56
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![BU of 5z56 by Molmil](/molmil-images/mine/5z56) | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | Deposit date: | 2018-01-17 | Release date: | 2018-09-19 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (5.1 Å) | Cite: | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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5Z57
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![BU of 5z57 by Molmil](/molmil-images/mine/5z57) | Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ALANINE, BUD13 homolog, ... | Authors: | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | Deposit date: | 2018-01-17 | Release date: | 2018-09-19 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Structure of the human activated spliceosome in three conformational states. Cell Res., 28, 2018
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7W5B
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![BU of 7w5b by Molmil](/molmil-images/mine/7w5b) | The cryo-EM structure of human C* complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2021-11-29 | Release date: | 2022-06-22 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7W5A
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![BU of 7w5a by Molmil](/molmil-images/mine/7w5a) | The cryo-EM structure of human pre-C*-II complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2021-11-29 | Release date: | 2022-06-22 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7W59
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![BU of 7w59 by Molmil](/molmil-images/mine/7w59) | The cryo-EM structure of human pre-C*-I complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2021-11-29 | Release date: | 2022-06-22 | Last modified: | 2022-08-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Mechanism of exon ligation by human spliceosome. Mol.Cell, 82, 2022
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7ABI
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![BU of 7abi by Molmil](/molmil-images/mine/7abi) | Human pre-Bact-2 spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2021-02-10 | Method: | ELECTRON MICROSCOPY (8 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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7A5P
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![BU of 7a5p by Molmil](/molmil-images/mine/7a5p) | Human C Complex Spliceosome - Medium-resolution PERIPHERY | Descriptor: | Cell division cycle 5-like protein, Crooked neck-like protein 1, Eukaryotic initiation factor 4A-III, ... | Authors: | Bertram, K, Kastner, B. | Deposit date: | 2020-08-21 | Release date: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome. Mol.Cell, 80, 2020
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6ZYM
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![BU of 6zym by Molmil](/molmil-images/mine/6zym) | Human C Complex Spliceosome - High-resolution CORE | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Corepressor interacting with RBPJ 1, ... | Authors: | Bertram, K, Kastner, B. | Deposit date: | 2020-08-02 | Release date: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome. Mol.Cell, 80, 2020
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7AAV
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![BU of 7aav by Molmil](/molmil-images/mine/7aav) | Human pre-Bact-2 spliceosome core structure | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-04 | Release date: | 2020-12-09 | Last modified: | 2020-12-30 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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7ABG
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![BU of 7abg by Molmil](/molmil-images/mine/7abg) | Human pre-Bact-1 spliceosome | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ... | Authors: | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | Deposit date: | 2020-09-07 | Release date: | 2020-12-23 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (7.8 Å) | Cite: | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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8I0V
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![BU of 8i0v by Molmil](/molmil-images/mine/8i0v) | The cryo-EM structure of human post-Bact complex | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, Crooked neck-like protein 1, ... | Authors: | Zhan, X, Lu, Y, Shi, Y. | Deposit date: | 2023-01-11 | Release date: | 2024-07-31 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for the activation of human spliceosome. Nat Commun, 15, 2024
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