7E1W
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![BU of 7e1w by Molmil](/molmil-images/mine/7e1w) | Cryo-EM structure of hybrid respiratory supercomplex consisting of Mycobacterium tuberculosis complexIII and Mycobacterium smegmatis complexIV in the presence of Q203 | Descriptor: | (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, 6-chloranyl-2-ethyl-N-[[4-[4-[4-(trifluoromethyloxy)phenyl]piperidin-1-yl]phenyl]methyl]imidazo[1,2-a]pyridine-3-carboxamide, ... | Authors: | Zhou, S, Wang, W, Gao, Y, Gong, H, Rao, Z. | Deposit date: | 2021-02-03 | Release date: | 2021-10-27 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (2.67 Å) | Cite: | Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates. Elife, 10, 2021
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7E8D
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![BU of 7e8d by Molmil](/molmil-images/mine/7e8d) | NSD2 E1099K mutant bound to nucleosome | Descriptor: | DNA (185-MER), Histone H2A type 1, Histone H2B type 1-J, ... | Authors: | Sengoku, T, Sato, K, Nishizawa, T, Nureki, O, Ogata, K. | Deposit date: | 2021-03-01 | Release date: | 2021-11-10 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of the regulation of the normal and oncogenic methylation of nucleosomal histone H3 Lys36 by NSD2. Nat Commun, 12, 2021
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7E9T
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![BU of 7e9t by Molmil](/molmil-images/mine/7e9t) | Nanometer resolution in situ structure of SARS-CoV-2 post-fusion spike | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2, ... | Authors: | Zhu, Y, Tai, L, Zhu, G, Yin, G, Sun, F. | Deposit date: | 2021-03-05 | Release date: | 2021-11-17 | Last modified: | 2022-03-23 | Method: | ELECTRON MICROSCOPY (10.9 Å) | Cite: | Nanometer-resolution in situ structure of the SARS-CoV-2 postfusion spike protein. Proc.Natl.Acad.Sci.USA, 118, 2021
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8OH4
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![BU of 8oh4 by Molmil](/molmil-images/mine/8oh4) | |
7BX1
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![BU of 7bx1 by Molmil](/molmil-images/mine/7bx1) | |
7BX0
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![BU of 7bx0 by Molmil](/molmil-images/mine/7bx0) | |
7BIU
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![BU of 7biu by Molmil](/molmil-images/mine/7biu) | XFEL crystal structure of cytochrome c peroxidase compound II | Descriptor: | Cytochrome c peroxidase, mitochondrial, HEME C | Authors: | Kwon, H, Tosha, T, Sugimoto, H, Raven, E.L, Moody, P.C.E. | Deposit date: | 2021-01-13 | Release date: | 2021-04-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.06 Å) | Cite: | XFEL Crystal Structures of Peroxidase Compound II. Angew.Chem.Int.Ed.Engl., 60, 2021
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7BE3
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![BU of 7be3 by Molmil](/molmil-images/mine/7be3) | Human Galectin-3 in complex with LacdiNAc | Descriptor: | 2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | Authors: | Trovao, F, Carvalho, A.L. | Deposit date: | 2020-12-22 | Release date: | 2021-04-21 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structural Insights into the Molecular Recognition Mechanism of the Cancer and Pathogenic Epitope, LacdiNAc by Immune-Related Lectins. Chemistry, 27, 2021
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8OF4
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![BU of 8of4 by Molmil](/molmil-images/mine/8of4) | Nucleosome Bound human SIRT6 (Composite) | Descriptor: | DNA (145-MER), Histone H2A type 1, Histone H2B, ... | Authors: | Smirnova, E, Bignon, E, Schultz, P, Papai, G, Ben-Shem, A. | Deposit date: | 2023-03-13 | Release date: | 2023-08-09 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Binding to nucleosome poises human SIRT6 for histone H3 deacetylation. Elife, 12, 2024
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8JPQ
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![BU of 8jpq by Molmil](/molmil-images/mine/8jpq) | SARS-CoV-2 Mpro in complex with D-5-96 | Descriptor: | ACETIC ACID, ALANINE, ISOLEUCINE, ... | Authors: | Liu, M, Huang, H. | Deposit date: | 2023-06-12 | Release date: | 2023-08-23 | Last modified: | 2024-06-12 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The S1'-S3' Pocket of the SARS-CoV-2 Main Protease Is Critical for Substrate Selectivity and Can Be Targeted with Covalent Inhibitors. Angew.Chem.Int.Ed.Engl., 62, 2023
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7BGC
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![BU of 7bgc by Molmil](/molmil-images/mine/7bgc) | human butyrylcholinesterase in complex with a tacrine-methylanacardate hybrid inhibitor | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Nachon, F, Salerno, A, Bolognesi, M.L. | Deposit date: | 2021-01-06 | Release date: | 2021-04-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease. J.Med.Chem., 64, 2021
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8JRU
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![BU of 8jru by Molmil](/molmil-images/mine/8jru) | Cryo-EM structure of the glucagon receptor bound to beta-arrestin 1 in ligand-free state | Descriptor: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, Nanobody 32, ... | Authors: | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-06-17 | Release date: | 2023-08-16 | Last modified: | 2023-09-13 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tail engagement of arrestin at the glucagon receptor. Nature, 620, 2023
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8JWY
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![BU of 8jwy by Molmil](/molmil-images/mine/8jwy) | Crystal structure of A2AR-T4L in complex with 2-118 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[2-oxidanylidene-1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]pyridin-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, Adenosine receptor A2a,Endolysin, ... | Authors: | Weng, Y, Chen, Y, Xu, Y, Song, G. | Deposit date: | 2023-06-29 | Release date: | 2023-08-16 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A 2 receptors. Sci China Life Sci, 67, 2024
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8JRV
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![BU of 8jrv by Molmil](/molmil-images/mine/8jrv) | Cryo-EM structure of the glucagon receptor bound to glucagon and beta-arrestin 1 | Descriptor: | Beta-arrestin 1 and single-chain fragment variable 30 (scFv30), Glucagon, HA signal peptide,HPC4 purification tag,Glucagon receptor,C-terminal tail of Vasopressin V2 receptor, ... | Authors: | Chen, K, Zhang, C, Lin, S, Zhao, Q, Wu, B. | Deposit date: | 2023-06-17 | Release date: | 2023-08-16 | Last modified: | 2023-09-13 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Tail engagement of arrestin at the glucagon receptor. Nature, 620, 2023
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7BIN
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![BU of 7bin by Molmil](/molmil-images/mine/7bin) | Salmonella export gate and rod refined in focussed C1 map | Descriptor: | Flagellar basal body rod protein FlgB, Flagellar basal-body rod protein FlgC, Flagellar basal-body rod protein FlgF, ... | Authors: | Johnson, S, Furlong, E, Lea, S.M. | Deposit date: | 2021-01-12 | Release date: | 2021-05-05 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular structure of the intact bacterial flagellar basal body. Nat Microbiol, 6, 2021
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7BC6
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![BU of 7bc6 by Molmil](/molmil-images/mine/7bc6) | Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5 | Descriptor: | Proton-coupled folate transporter, nanobody | Authors: | Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S. | Deposit date: | 2020-12-18 | Release date: | 2021-05-12 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis of antifolate recognition and transport by PCFT. Nature, 595, 2021
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7C25
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![BU of 7c25 by Molmil](/molmil-images/mine/7c25) | Glycosidase Wild Type at pH8.0 | Descriptor: | AMMONIUM ION, CITRIC ACID, GLYCEROL, ... | Authors: | Tagami, T, Kikuchi, A, Okuyama, M, Kimura, A. | Deposit date: | 2020-05-07 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.505 Å) | Cite: | Structural insights reveal the second base catalyst of isomaltose glucohydrolase. Febs J., 289, 2022
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7C24
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![BU of 7c24 by Molmil](/molmil-images/mine/7c24) | Glycosidase F290Y at pH8.0 | Descriptor: | AMMONIUM ION, GLYCEROL, Isomaltose glucohydrolase | Authors: | Tagami, T, Kikuchi, A, Okuyama, M, Kimura, A. | Deposit date: | 2020-05-07 | Release date: | 2021-05-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Structural insights reveal the second base catalyst of isomaltose glucohydrolase. Febs J., 289, 2022
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8JWZ
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![BU of 8jwz by Molmil](/molmil-images/mine/8jwz) | Crystal structure of A2AR-T4L in complex with AB928 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, Adenosine receptor A2a,Endolysin, ... | Authors: | Weng, Y, Chen, Y, Xu, Y, Song, G. | Deposit date: | 2023-06-29 | Release date: | 2023-08-16 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A 2 receptors. Sci China Life Sci, 67, 2024
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7BL4
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![BU of 7bl4 by Molmil](/molmil-images/mine/7bl4) | in vitro reconstituted 50S-ObgE-GMPPNP-RsfS particle | Descriptor: | 23S ribosomal RNA, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | Authors: | Hilal, T, Nikolay, R, Spahn, C.M.T. | Deposit date: | 2021-01-18 | Release date: | 2021-05-12 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Snapshots of native pre-50S ribosomes reveal a biogenesis factor network and evolutionary specialization. Mol.Cell, 81, 2021
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7CPJ
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![BU of 7cpj by Molmil](/molmil-images/mine/7cpj) | ycbZ-stalled 70S ribosome | Descriptor: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Yokoyama, T, Shirouzu, M, Ito, T. | Deposit date: | 2020-08-07 | Release date: | 2021-12-08 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The landscape of translational stall sites in bacteria revealed by monosome and disome profiling. Rna, 28, 2022
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8JPO
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![BU of 8jpo by Molmil](/molmil-images/mine/8jpo) | Cryo-EM structure of ATP bound human ClC-6 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 6, ... | Authors: | Zhang, S.S. | Deposit date: | 2023-06-12 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Molecular basis of ClC-6 function and its impairment in human disease Sci Adv, 2023
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8JPJ
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![BU of 8jpj by Molmil](/molmil-images/mine/8jpj) | Cryo-EM structure of ClC-6 apo state | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter 6 | Authors: | Zhang, S.S. | Deposit date: | 2023-06-12 | Release date: | 2023-09-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Molecular basis of ClC-6 function and its impairment in human disease Sci Adv, 2023
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8JZX
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![BU of 8jzx by Molmil](/molmil-images/mine/8jzx) | SLC15A4 inhibitor complex | Descriptor: | 2-(4-ethoxyphenyl)-N-[3-[(2R)-2-methylpiperidin-1-yl]propyl]quinoline-4-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | Authors: | Zhang, S.S, Chen, X.D, Xie, M. | Deposit date: | 2023-07-06 | Release date: | 2023-09-27 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | A conformation-locking inhibitor of SLC15A4 with TASL proteostatic anti-inflammatory activity. Nat Commun, 14, 2023
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8OEE
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![BU of 8oee by Molmil](/molmil-images/mine/8oee) | |