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4Z3S
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BU of 4z3s by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with antibiotic A201A, mRNA and three tRNAs in the A, P and E sites at 2.65A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 3'-deoxy-3'-{[(2E)-3-(4-{[(4Z)-6-O-(6-deoxy-3,4-di-O-methyl-alpha-D-mannopyranosyl)-5-O-methyl-alpha-D-threo-hex-4-enofuranosyl]oxy}phenyl)-2-methylprop-2-enoyl]amino}-N,N-dimethyladenosine, ...
Authors:Polikanov, Y.S, Starosta, A.L, Juette, M.F, Altman, R.B, Terry, D.S, Lu, W, Burnett, B.J, Dinos, G, Reynolds, K, Blanchard, S.C, Steitz, T.A, Wilson, D.N.
Deposit date:2015-03-31
Release date:2015-06-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.
Mol.Cell, 58, 2015
8PPL
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BU of 8ppl by Molmil
MERS-CoV Nsp1 bound to the human 43S pre-initiation complex
Descriptor: 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ...
Authors:Schubert, K, Karousis, E.D, Ban, I, Lapointe, C.P, Leibundgut, M, Baeumlin, E, Kummerant, E, Scaiola, A, Schoenhut, T, Ziegelmueller, J, Puglisi, J.D, Muehlemann, O, Ban, N.
Deposit date:2023-07-07
Release date:2023-10-18
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Universal features of Nsp1-mediated translational shutdown by coronaviruses.
Mol.Cell, 83, 2023
7NWT
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BU of 7nwt by Molmil
Initiated 70S ribosome in complex with 2A protein from encephalomyocarditis virus (EMCV)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Hill, C.H, Napthine, S, Pekarek, L, Kibe, A, Firth, A.E, Graham, S.C, Caliskan, N, Brierley, I.
Deposit date:2021-03-17
Release date:2021-12-15
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch
Nat Commun, 12, 2021
6XZA
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BU of 6xza by Molmil
E. coli 70S ribosome in complex with dirithromycin, and deacylated tRNA(iMet) (focused classification).
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Pichkur, E.B, Polikanov, Y.S, Myasnikov, A.G, Konevega, A.L.
Deposit date:2020-02-03
Release date:2020-11-04
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Insights into the improved macrolide inhibitory activity from the high-resolution cryo-EM structure of dirithromycin bound to the E. coli 70S ribosome.
Rna, 26, 2020
7N30
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BU of 7n30 by Molmil
Elongating 70S ribosome complex in a hybrid-H2* pre-translocation (PRE-H2*) conformation
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C.
Deposit date:2021-05-30
Release date:2021-07-14
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
7M4X
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BU of 7m4x by Molmil
A. baumannii Ribosome-Eravacycline complex: P-site tRNA 70S
Descriptor: 16s Ribosomal RNA, 23s ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Morgan, C.E, Yu, E.W.
Deposit date:2021-03-22
Release date:2021-05-19
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii.
Mbio, 12, 2021
7Q0R
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BU of 7q0r by Molmil
Structure of the Candida albicans 80S ribosome in complex with blasticidin s
Descriptor: 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0, ...
Authors:Kolosova, O, Zgadzay, Y, Stetsenko, A, Jenner, L, Guskov, A, Yusupova, G, Yusupov, M.
Deposit date:2021-10-16
Release date:2022-05-25
Last modified:2022-06-08
Method:ELECTRON MICROSCOPY (2.67 Å)
Cite:E-site drug specificity of the human pathogen Candida albicans ribosome.
Sci Adv, 8, 2022
8JDM
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BU of 8jdm by Molmil
Structure of the Human cytoplasmic Ribosome with human tRNA Tyr(GalQ34) and mRNA(UAU) (rotated state)
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T.
Deposit date:2023-05-14
Release date:2023-12-06
Last modified:2023-12-27
Method:ELECTRON MICROSCOPY (2.67 Å)
Cite:Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth.
Cell, 186, 2023
8HU1
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BU of 8hu1 by Molmil
E. coli 70S ribosome complexed with tRNA_Ile2 bearing L34 and ct6A37 in classical state
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Akiyama, N, Ishiguro, K, Yokoyama, T, Shirouzu, M, Suzuki, T.
Deposit date:2022-12-22
Release date:2024-04-03
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Structural insights into the decoding capability of isoleucine tRNAs with lysidine and agmatidine.
Nat.Struct.Mol.Biol., 31, 2024
7N31
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BU of 7n31 by Molmil
Elongating 70S ribosome complex in a post-translocation (POST) conformation
Descriptor: 1,4-DIAMINOBUTANE, 16S rRNA, 23S rRNA, ...
Authors:Rundlet, E.J, Holm, M, Schacherl, M, Natchiar, K.S, Altman, R.B, Spahn, C.M.T, Myasnikov, A.G, Blanchard, S.C.
Deposit date:2021-05-31
Release date:2021-07-14
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Structural basis of early translocation events on the ribosome.
Nature, 595, 2021
7OE0
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BU of 7oe0 by Molmil
E. coli pre-30S delta rbfA ribosomal subunit class F
Descriptor: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Maksimova, E, Korepanov, A, Baymukhametov, T, Kravchenko, O, Stolboushkina, E.
Deposit date:2021-04-30
Release date:2021-07-14
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:RbfA Is Involved in Two Important Stages of 30S Subunit Assembly: Formation of the Central Pseudoknot and Docking of Helix 44 to the Decoding Center.
Int J Mol Sci, 22, 2021
4V8I
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BU of 4v8i by Molmil
Crystal structure of YfiA bound to the 70S ribosome.
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ...
Authors:Polikanov, Y.S, Blaha, G.M, Steitz, T.A.
Deposit date:2011-12-12
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:How hibernation factors RMF, HPF, and YfiA turn off protein synthesis.
Science, 336, 2012
7ZAH
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BU of 7zah by Molmil
Cryo-EM structure of a Pyrococcus abyssi 30S bound to Met-initiator tRNA, mRNA, aIF1A and aIF5B
Descriptor: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R.
Deposit date:2022-03-22
Release date:2022-08-03
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
6AZ1
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BU of 6az1 by Molmil
Cryo-EM structure of the small subunit of Leishmania ribosome bound to paromomycin
Descriptor: E-site tRNA, LACK1, MAGNESIUM ION, ...
Authors:Shalev-Benami, M, Zhang, Y, Rozenberg, H, Matzov, D, Zimmerman, E, Bashan, A, Jaffe, C.L, Yonath, A, Skiniotis, G.
Deposit date:2017-09-09
Release date:2017-12-06
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Nat Commun, 8, 2017
7ZTA
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BU of 7zta by Molmil
Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Leroy, E.C, Perry, T.N, Renault, T.T, Innis, C.A.
Deposit date:2022-05-09
Release date:2023-04-12
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs.
Nat.Chem.Biol., 19, 2023
7MPJ
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BU of 7mpj by Molmil
Stm1 bound vacant 80S structure isolated from wild-type
Descriptor: 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ...
Authors:Rai, J, Zhao, Y, Li, H.
Deposit date:2021-05-04
Release date:2022-05-11
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
7R81
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BU of 7r81 by Molmil
Structure of the translating Neurospora crassa ribosome arrested by cycloheximide
Descriptor: 18S rRNA, 26S rRNA, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Shen, L, Su, Z, Yang, K, Wu, C, Becker, T, Bell-Pedersen, D, Zhang, J, Sachs, M.S.
Deposit date:2021-06-25
Release date:2021-12-01
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure of the translating Neurospora ribosome arrested by cycloheximide
Proc.Natl.Acad.Sci.USA, 118, 2021
4W2H
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BU of 4w2h by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with pactamycin (co-crystallized), mRNA and deacylated tRNA in the P site
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ...
Authors:Polikanov, Y.S, Osterman, I.A, Szal, T, Tashlitsky, V.N, Serebryakova, M.V, Kusochek, P, Bulkley, D, Malanicheva, I.A, Efimenko, T.A, Efremenkova, O.V, Konevega, A.L, Shaw, K.J, Bogdanov, A.A, Rodnina, M.V, Dontsova, O.A, Mankin, A.S, Steitz, T.A, Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
8G2D
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BU of 8g2d by Molmil
Crystal structure of the wild-type Thermus thermophilus 70S ribosome in complex with tylosin, mRNA, deacylated A- and E-site tRNAphe, and deacylated P-site tRNAmet at 2.70A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Aleksandrova, E.V, Wu, K.J.Y, Tresco, B.I.C, Syroegin, E.A, Killeavy, E.E, Balasanyants, S.M, Svetlov, M.S, Gregory, S.T, Atkinson, G.C, Myers, A.G, Polikanov, Y.S.
Deposit date:2023-02-03
Release date:2023-12-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it.
Nat.Chem.Biol., 2024
4W2I
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BU of 4w2i by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with negamycin, mRNA and three deacylated tRNAs in the A, P and E sites
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ...
Authors:Polikanov, Y.S, Szal, T, Jiang, F, Gupta, P, Matsuda, R, Shiozuka, M, Steitz, T.A, Vazquez-Laslop, N, Mankin, A.S.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA.
Mol.Cell, 56, 2014
7XNX
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BU of 7xnx by Molmil
High resolution cry-EM structure of the human 80S ribosome from SNORD127+/+ Kasumi-1 cells
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Cheng, J, Beckmann, R.
Deposit date:2022-04-30
Release date:2023-04-05
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:A Dynamic rRNA Ribomethylome Drives Stemness in Acute Myeloid Leukemia.
Cancer Discov, 13, 2023
6ZM7
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BU of 6zm7 by Molmil
SARS-CoV-2 Nsp1 bound to the human CCDC124-80S-EBP1 ribosome complex
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Thoms, M, Buschauer, R, Ameismeier, M, Denk, T, Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R.
Deposit date:2020-07-01
Release date:2020-07-29
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
Science, 369, 2020
7UNV
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BU of 7unv by Molmil
Pseudomonas aeruginosa 70S ribosome initiation complex bound to IF2-GDPCP (structure II-A)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Basu, R.S, Sherman, M.B, Gagnon, M.G.
Deposit date:2022-04-11
Release date:2022-06-22
Last modified:2024-02-14
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Compact IF2 allows initiator tRNA accommodation into the P site and gates the ribosome to elongation
Nat Commun, 13, 2022
7JQB
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BU of 7jqb by Molmil
SARS-CoV-2 Nsp1 and rabbit 40S ribosome complex
Descriptor: 40S ribosomal protein S21, 40S ribosomal protein S24, 40S ribosomal protein S26, ...
Authors:Yuan, S, Xiong, Y.
Deposit date:2020-08-10
Release date:2020-12-02
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Nonstructural Protein 1 of SARS-CoV-2 Is a Potent Pathogenicity Factor Redirecting Host Protein Synthesis Machinery toward Viral RNA.
Mol.Cell, 80, 2020
6ZXH
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BU of 6zxh by Molmil
Cryo-EM structure of a late human pre-40S ribosomal subunit - State H2
Descriptor: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
Authors:Ameismeier, M, Zemp, I, van den Heuvel, J, Thoms, M, Berninghausen, O, Kutay, U, Beckmann, R.
Deposit date:2020-07-29
Release date:2020-12-16
Last modified:2024-04-24
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for the final steps of human 40S ribosome maturation.
Nature, 587, 2020

221051

数据于2024-06-12公开中

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