PDB: 658 resultsInfo pagesStatus searchChemie searchBIRD

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6WK8	Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in complex with phenylguanidinium Descriptor: 1-phenylguanidine, DECYL-BETA-D-MALTOPYRANOSIDE, Dodecyldimethylphosphine oxide, ... Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2020-04-15 Release date: 2020-10-28 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.53 Å) Cite: The structural basis of promiscuity in small multidrug resistance transporters. Nat Commun, 11, 2020
6WK5	Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters Descriptor: L10 monobody, Multidrug resistance protein, SMR family Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2020-04-15 Release date: 2020-10-28 Last modified: 2020-12-09 Method: X-RAY DIFFRACTION (3.5 Å) Cite: The structural basis of promiscuity in small multidrug resistance transporters. Nat Commun, 11, 2020
6WK9	Crystal structure of Gdx-Clo from Small Multidrug Resistance family of transporters in complex with octylguanidinium Descriptor: DECYL-BETA-D-MALTOPYRANOSIDE, L10 monobody, Multidrug resistance protein, ... Authors: Kermani, A.A, Stockbridge, R.B. Deposit date: 2020-04-15 Release date: 2020-10-28 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.32 Å) Cite: The structural basis of promiscuity in small multidrug resistance transporters. Nat Commun, 11, 2020
7WLS	Crystal structure of the multidrug efflux transporter BpeB from Burkholderia pseudomallei Descriptor: Efflux pump membrane transporter, TETRAETHYLENE GLYCOL, UNDECYL-MALTOSIDE Authors: Kato, T, Hung, L.-W, Yamashita, E, Okada, U, Terwilliger, T.C, Murakami, S. Deposit date: 2022-01-13 Release date: 2023-07-19 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Crystal structures of multidrug efflux transporters from Burkholderia pseudomallei suggest details of transport mechanism. Proc.Natl.Acad.Sci.USA, 120, 2023
7WLV	Crystal Structure of the Multidrug effulx transporter BpeF from Burkholderia pseudomallei. Descriptor: DODECYL-BETA-D-MALTOSIDE, Efflux pump membrane transporter Authors: Kato, T, Hung, L.-W, Yamashita, E, Okada, U, Terwilliger, T.C, Murakami, S. Deposit date: 2022-01-13 Release date: 2023-07-19 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structures of multidrug efflux transporters from Burkholderia pseudomallei suggest details of transport mechanism. Proc.Natl.Acad.Sci.USA, 120, 2023
6UY0	Cryo-EM structure of wild-type bovine multidrug resistance protein 1 (MRP1) under active turnover conditions Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, ... Authors: Johnson, Z.L, Chen, J. Deposit date: 2019-11-09 Release date: 2020-06-10 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Characterization of the kinetic cycle of an ABC transporter by single-molecule and cryo-EM analyses. Elife, 9, 2020
8T1P	Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ADPVi: BmrCD_OC-ADPVi Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, ... Authors: Tang, Q, Mchaourab, H.S. Deposit date: 2023-06-02 Release date: 2023-11-15 Last modified: 2023-11-22 Method: ELECTRON MICROSCOPY (2.96 Å) Cite: Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
8SZC	Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-1HT/ATP Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Tang, Q, Mchaourab, H. Deposit date: 2023-05-29 Release date: 2023-11-15 Last modified: 2023-11-22 Method: ELECTRON MICROSCOPY (3.06 Å) Cite: Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
8T3K	Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP2 Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ... Authors: Tang, Q, Mchaourab, H. Deposit date: 2023-06-07 Release date: 2023-11-29 Method: ELECTRON MICROSCOPY (3.33 Å) Cite: Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
8FMV	Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to substrate and ATP: BmrCD_IF-2HT/ATP Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2'-(4-ETHOXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ADENOSINE-5'-TRIPHOSPHATE, ... Authors: Tang, Q, Mchaourab, H. Deposit date: 2022-12-24 Release date: 2023-11-15 Last modified: 2023-11-22 Method: ELECTRON MICROSCOPY (3.34 Å) Cite: Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
8FHK	Heterodimeric ABC transporter BmrCD in the occluded conformation bound to ATP: BmrCD_OC-ATP Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Tang, Q, Mchaourab, H. Deposit date: 2022-12-14 Release date: 2023-11-15 Last modified: 2023-11-22 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter. Nat Commun, 14, 2023
6BHU	Cryo-EM structure of ATP-bound, outward-facing bovine multidrug resistance protein 1 (MRP1) Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL, MAGNESIUM ION, ... Authors: Johnson, Z.L, Chen, J. Deposit date: 2017-10-31 Release date: 2017-12-27 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.14 Å) Cite: ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1. Cell, 172, 2018
8FPF	Heterodimeric ABC transporter BmrCD in the inward-facing conformation bound to ATP: BmrCD_IF-ATP Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ADENOSINE-5'-TRIPHOSPHATE, Probable multidrug resistance ABC transporter ATP-binding/permease protein YheH, ... Authors: Qingyu, T, Hassane, M. Deposit date: 2023-01-04 Release date: 2023-11-22 Method: ELECTRON MICROSCOPY (3.27 Å) Cite: Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter Nat Commun, 14, 2023
2V50	The Missing Part of the Bacterial MexAB-OprM System: Structural determination of the Multidrug Exporter MexB Descriptor: DODECYL-BETA-D-MALTOSIDE, MULTIDRUG RESISTANCE PROTEIN MEXB Authors: Sennhauser, G, Bukowska, M.A, Gruetter, M.G. Deposit date: 2008-10-01 Release date: 2009-05-19 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal Structure of the Multidrug Exporter Mexb from Pseudomonas Aeruginosa. J.Mol.Biol., 389, 2009
8DEW	Cryo-electron microscopy structure of Neisseria gonorrhoeae multidrug efflux pump MtrD with LL-37 complex Descriptor: Antibacterial peptide LL-37, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE Authors: Lyu, M, Yu, E.W. Deposit date: 2022-06-21 Release date: 2022-09-14 Last modified: 2024-06-12 Method: ELECTRON MICROSCOPY (2.89 Å) Cite: Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump. Microbiol Spectr, 10, 2022
8DEU	Cryo-electron microscopy structure of Neisseria gonorrhoeae multidrug efflux pump MtrD with CASP peptide complex Descriptor: CASP peptide, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE Authors: Lyu, M, Yu, E.W. Deposit date: 2022-06-21 Release date: 2022-09-14 Last modified: 2022-11-09 Method: ELECTRON MICROSCOPY (2.95 Å) Cite: Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump. Microbiol Spectr, 10, 2022
8DEV	Cryo-electron microscopy structure of Neisseria gonorrhoeae multidrug efflux pump MtrD with colistin complex Descriptor: Colistin, Efflux pump membrane transporter, PHOSPHATIDYLETHANOLAMINE Authors: Lyu, M, Yu, E.W. Deposit date: 2022-06-21 Release date: 2022-09-14 Last modified: 2022-11-09 Method: ELECTRON MICROSCOPY (3.08 Å) Cite: Structural Basis of Peptide-Based Antimicrobial Inhibition of a Resistance-Nodulation-Cell Division Multidrug Efflux Pump. Microbiol Spectr, 10, 2022
1JTX	Crystal structure of the multidrug binding transcriptional regulator QacR bound to crystal violet Descriptor: CRYSTAL VIOLET, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION Authors: Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. Deposit date: 2001-08-22 Release date: 2001-12-07 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural mechanisms of QacR induction and multidrug recognition. Science, 294, 2001
1JUP	Crystal structure of the multidrug binding transcriptional repressor QacR bound to malachite green Descriptor: HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, MALACHITE GREEN, SULFATE ION Authors: Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. Deposit date: 2001-08-24 Release date: 2001-12-12 Last modified: 2023-08-16 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural mechanisms of QacR induction and multidrug recognition. Science, 294, 2001
5NG5	multi-drug efflux; membrane transport; RND superfamily; Drug resistance Descriptor: 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile, Multidrug efflux pump accessory protein AcrZ, Multidrug efflux pump subunit AcrA, ... Authors: Wang, Z, Fan, G, Hryc, C.F, Blaza, J.N, Serysheva, I.I, Schmid, M.F, Chiu, W, Luisi, B.F, Du, D. Deposit date: 2017-03-16 Release date: 2017-04-19 Last modified: 2017-08-02 Method: ELECTRON MICROSCOPY (6.5 Å) Cite: An allosteric transport mechanism for the AcrAB-TolC Multidrug Efflux Pump. Elife, 6, 2017
8VXU	Crystal structure of Gdx-Clo A60T from Small Multidrug Resistance family of transporters in complex with cetyltrimetylammonium Descriptor: CETYL-TRIMETHYL-AMMONIUM, L10 Monobody, Multidrug resistance protein, ... Authors: Burata, O.E, Stockbridge, R.B. Deposit date: 2024-02-06 Release date: 2024-05-08 Last modified: 2024-06-26 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Peripheral positions encode transport specificity in the small multidrug resistance exporters. Proc.Natl.Acad.Sci.USA, 121, 2024
6VXF	Structure of apo-closed ABCG2 Descriptor: Broad substrate specificity ATP-binding cassette transporter ABCG2 Authors: Orlando, B.J, Maofu, L. Deposit date: 2020-02-21 Release date: 2020-05-13 Last modified: 2020-05-20 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
6VXJ	Structure of ABCG2 bound to SN38 Descriptor: 7-ethyl-10-hydroxycamptothecin, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL Authors: Orlando, B.J, Liao, M. Deposit date: 2020-02-22 Release date: 2020-05-13 Last modified: 2020-05-20 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
6VXH	Structure of ABCG2 bound to imatinib Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL Authors: Orlando, B.J, Liao, M. Deposit date: 2020-02-21 Release date: 2020-05-13 Last modified: 2020-05-20 Method: ELECTRON MICROSCOPY (4 Å) Cite: ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020
6VXI	Structure of ABCG2 bound to mitoxantrone Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL Authors: Orlando, B.J, Liao, M. Deposit date: 2020-02-21 Release date: 2020-05-13 Last modified: 2020-05-20 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: ABCG2 transports anticancer drugs via a closed-to-open switch. Nat Commun, 11, 2020

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