8V8D
 
 | | Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and PNU-120596 asymmetric state 2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Burke, S.M, Noviello, C.M, Hibbs, R.E. | | Deposit date: | 2023-12-05 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
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8V86
 | | Alpha7-nicotinic acetylcholine receptor bound to GAT107 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, ... | | Authors: | Burke, S.M, Noviello, C.M, Hibbs, R.E. | | Deposit date: | 2023-12-04 | | Release date: | 2024-02-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (2.47 Å) | | Cite: | Structural mechanisms of alpha 7 nicotinic receptor allosteric modulation and activation.
Cell, 187, 2024
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8QQM
 | | nicotinic acetylcholine receptor in intact synaptic membrane | | Descriptor: | Acetylcholine receptor subunit alpha, Acetylcholine receptor subunit beta, Acetylcholine receptor subunit delta, ... | | Authors: | Unwin, N. | | Deposit date: | 2023-10-05 | | Release date: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Influence of lipid bilayer on the structure of the muscle-type nicotinic acetylcholine receptor.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8SGO
 | | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Legesse, D.H, Fan, C, Teng, J, Zhuang, Y, Howard, R.J, Noviello, C.M, Lindahl, E, Hibbs, R.E. | | Deposit date: | 2023-04-12 | | Release date: | 2023-08-30 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | Structural insights into opposing actions of neurosteroids on GABA A receptors.
Nat Commun, 14, 2023
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8SI9
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8RH9
 | | CryoEM structure of human rho1 GABAA receptor in complex with pregnenolone sulfate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-15 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.21 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8RH7
 | | CryoEM structure of human rho1 GABAA receptor in complex with GABA and estradiol in primed state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ESTRADIOL, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-15 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.78 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8RH8
 | | CryoEM structure of human rho1 GABAA receptor in complex with GABA and estradiol in desensitized state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-15 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.66 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8RHG
 | | CryoEM structure of human rho1 GABAA receptor in complex with GABA and pregnenolone sulfate | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-15 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8RH4
 | | CryoEM structure of human rho1 GABAA receptor in complex with estradiol | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, DECANE, ... | | Authors: | Chen, F, John, C, Rebecca, J.H, Erik, L. | | Deposit date: | 2023-12-14 | | Release date: | 2024-08-28 | | Method: | ELECTRON MICROSCOPY (2.52 Å) | | Cite: | Divergent mechanisms of steroid inhibition in the human rho1 GABAA receptor
Nat Commun, 2024
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8SID
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8ST0
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8ST1
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8ST2
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8SSZ
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8ST4
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8ST3
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7PBD
 | | a1b3 GABA-A receptor + GABA | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | | Authors: | Miller, P.S, Kasaragod, V.B. | | Deposit date: | 2021-08-02 | | Release date: | 2022-02-09 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (3.04 Å) | | Cite: | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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7PBZ
 | | a1b3 GABA-A receptor + GABA + Zn2+ | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ... | | Authors: | Miller, P.S, Kasaragod, V.B. | | Deposit date: | 2021-08-03 | | Release date: | 2022-02-09 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.79 Å) | | Cite: | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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7PC0
 | | GABA-A receptor bound by a-Cobratoxin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-cobratoxin, ... | | Authors: | Kasaragod, V.B, Miller, P.S. | | Deposit date: | 2021-08-03 | | Release date: | 2022-02-09 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Mechanisms of inhibition and activation of extrasynaptic alpha beta GABA A receptors.
Nature, 602, 2022
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7QL5
 | | Torpedo muscle-type nicotinic acetylcholine receptor - nicotine-bound conformation | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | | Deposit date: | 2021-12-19 | | Release date: | 2022-02-09 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor.
Neuron, 110, 2022
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7QKO
 | | Torpedo muscle-type nicotinic acetylcholine receptor - Resting conformation | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Acetylcholine receptor subunit alpha, Acetylcholine receptor subunit beta, ... | | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | | Deposit date: | 2021-12-18 | | Release date: | 2022-02-09 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor.
Neuron, 110, 2022
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7QL6
 | | Torpedo muscle-type nicotinic acetylcholine receptor - carbamylcholine-bound conformation | | Descriptor: | 2-[(AMINOCARBONYL)OXY]-N,N,N-TRIMETHYLETHANAMINIUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Zarkadas, E, Pebay-Peyroula, E, Baenziger, J, Nury, H. | | Deposit date: | 2021-12-19 | | Release date: | 2022-02-09 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor.
Neuron, 110, 2022
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7QNC
 | | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one, ... | | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | | Deposit date: | 2021-12-20 | | Release date: | 2022-04-13 | | Last modified: | 2022-04-20 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
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7QN5
 | | Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25 | | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | | Deposit date: | 2021-12-20 | | Release date: | 2022-04-13 | | Last modified: | 2022-05-04 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Differential assembly diversifies GABA A receptor structures and signalling.
Nature, 604, 2022
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