8SID

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus dehydroepiandrosterone sulfate

Summary for 8SID

• Entry DOI: 10.2210/pdb8sid/pdb
• EMDB information: 40503 40506
• Descriptor: Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, ... (14 entities in total)
• Functional Keywords: ion channel, neurosteroids, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 370900.71

Authors

Legesse, D.H.,Hibbs, R.E. (deposition date: 2023-04-14, release date: 2023-08-30, Last modification date: 2023-11-15)

• Primary citation: Legesse, D.H.,Fan, C.,Teng, J.,Zhuang, Y.,Howard, R.J.,Noviello, C.M.,Lindahl, E.,Hibbs, R.E.; Structural insights into opposing actions of neurosteroids on GABA A receptors.; Nat Commun, 14:5091-5091, 2023; PubMed: 37607940; DOI: 10.1038/s41467-023-40800-1

Experimental method

ELECTRON MICROSCOPY (2.71 Å)