8SGO

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate

Summary for 8SGO

Entry DOI	10.2210/pdb8sgo/pdb
EMDB information	40462
Descriptor	Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, PHOSPHATIDYLETHANOLAMINE, ... (13 entities in total)
Functional Keywords	ion channel, neurosteroids, transport protein-immune system complex, transport protein/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	9
Total formula weight	370168.68
Authors	Legesse, D.H.,Fan, C.,Teng, J.,Zhuang, Y.,Howard, R.J.,Noviello, C.M.,Lindahl, E.,Hibbs, R.E. (deposition date: 2023-04-12, release date: 2023-08-30, Last modification date: 2023-11-15)
Primary citation	Legesse, D.H.,Fan, C.,Teng, J.,Zhuang, Y.,Howard, R.J.,Noviello, C.M.,Lindahl, E.,Hibbs, R.E. Structural insights into opposing actions of neurosteroids on GABA A receptors. Nat Commun, 14:5091-5091, 2023 Cited by PubMed: 37607940 DOI: 10.1038/s41467-023-40800-1 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.65 Å)

Structure validation