8ST3

The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium

Summary for 8ST3

• Entry DOI: 10.2210/pdb8st3/pdb
• EMDB information: 40752 40753 40754 40755 40756 40757
• Descriptor: Neuronal acetylcholine receptor subunit alpha-4, Neuronal acetylcholine receptor subunit beta-2, IgG1 Kappa Light Chain, ... (10 entities in total)
• Functional Keywords: cys-loop ligand-gated pentameric ion channels, cation-selective channel, acetylcholine, calcium, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 11
• Total formula weight: 466216.63

Authors

Kang, G.,Hibbs, R.E. (deposition date: 2023-05-09, release date: 2024-02-07, Last modification date: 2024-11-06)

Primary citation

Mazzaferro, S.,Kang, G.,Natarajan, K.,Hibbs, R.E.,Sine, S.M.
Structural bases for stoichiometry-selective calcium potentiation of a neuronal nicotinic receptor.
Br.J.Pharmacol., 181:1973-1992, 2024

PubMed Abstract: α4β2 nicotinic acetylcholine (nACh) receptors assemble in two stoichiometric forms, one of which is potentiated by calcium. The sites of calcium binding that underpin potentiation are not known.

PubMed: 38454578
DOI: 10.1111/bph.16321

Experimental method

ELECTRON MICROSCOPY (2.93 Å)