- EMDB-40756: The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acet... -
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Basic information
Entry
Database: EMDB / ID: EMD-40756
Title
The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium
Map data
Sample
Complex: A complex of three Fab fragments with the 2alpha3beta stoichiometry of human alpha4beta2 nicotinic receptor bound to acetylcholine and calcium
Protein or peptide: Neuronal acetylcholine receptor subunit alpha-4
Protein or peptide: Neuronal acetylcholine receptor subunit beta-2
Protein or peptide: IgG1 Kappa Light Chain
Protein or peptide: IgG1 Heavy Chain
Ligand: 2-acetamido-2-deoxy-beta-D-glucopyranose
Ligand: ACETYLCHOLINE
Ligand: CALCIUM ION
Ligand: SODIUM ION
Ligand: water
Keywords
cys-loop ligand-gated pentameric ion channels / cation-selective channel / acetylcholine / calcium / TRANSPORT PROTEIN
Function / homology
Function and homology information
vestibulocochlear nerve development / lateral geniculate nucleus development / regulation of circadian sleep/wake cycle, REM sleep / regulation of synaptic transmission, dopaminergic / quaternary ammonium group binding / synaptic transmission involved in micturition / Highly sodium permeable postsynaptic acetylcholine nicotinic receptors / Highly calcium permeable nicotinic acetylcholine receptors / optic nerve morphogenesis / response to acetylcholine ...vestibulocochlear nerve development / lateral geniculate nucleus development / regulation of circadian sleep/wake cycle, REM sleep / regulation of synaptic transmission, dopaminergic / quaternary ammonium group binding / synaptic transmission involved in micturition / Highly sodium permeable postsynaptic acetylcholine nicotinic receptors / Highly calcium permeable nicotinic acetylcholine receptors / optic nerve morphogenesis / response to acetylcholine / Highly calcium permeable postsynaptic nicotinic acetylcholine receptors / central nervous system projection neuron axonogenesis / acetylcholine-gated channel complex / regulation of dopamine metabolic process / cholinergic synapse / negative regulation of action potential / behavioral response to nicotine / positive regulation of dopamine secretion / acetylcholine receptor activity / inhibitory postsynaptic potential / synaptic transmission, cholinergic / acetylcholine binding / postsynaptic specialization membrane / nervous system process / acetylcholine receptor signaling pathway / acetylcholine-gated monoatomic cation-selective channel activity / regulation of synapse assembly / action potential / regulation of dendrite morphogenesis / heterocyclic compound binding / regulation of dopamine secretion / B cell activation / plasma membrane raft / associative learning / membrane depolarization / social behavior / ligand-gated monoatomic ion channel activity / smooth muscle contraction / monoatomic ion transport / positive regulation of B cell proliferation / sensory perception of pain / visual perception / response to cocaine / learning / locomotory behavior / regulation of membrane potential / sensory perception of sound / response to nicotine / visual learning / memory / cognition / calcium ion transport / presynaptic membrane / chemical synaptic transmission / postsynaptic membrane / response to ethanol / response to oxidative stress / response to hypoxia / neuron projection / external side of plasma membrane / DNA repair / neuronal cell body / synapse / dendrite / protein-containing complex binding / signal transduction / membrane / plasma membrane Similarity search - Function
Entire : A complex of three Fab fragments with the 2alpha3beta stoichiomet...
Entire
Name: A complex of three Fab fragments with the 2alpha3beta stoichiometry of human alpha4beta2 nicotinic receptor bound to acetylcholine and calcium
Components
Complex: A complex of three Fab fragments with the 2alpha3beta stoichiometry of human alpha4beta2 nicotinic receptor bound to acetylcholine and calcium
Protein or peptide: Neuronal acetylcholine receptor subunit alpha-4
Protein or peptide: Neuronal acetylcholine receptor subunit beta-2
Protein or peptide: IgG1 Kappa Light Chain
Protein or peptide: IgG1 Heavy Chain
Ligand: 2-acetamido-2-deoxy-beta-D-glucopyranose
Ligand: ACETYLCHOLINE
Ligand: CALCIUM ION
Ligand: SODIUM ION
Ligand: water
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Supramolecule #1: A complex of three Fab fragments with the 2alpha3beta stoichiomet...
Supramolecule
Name: A complex of three Fab fragments with the 2alpha3beta stoichiometry of human alpha4beta2 nicotinic receptor bound to acetylcholine and calcium type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#4
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