8ST3
The 2alpha3beta stoichiometry of human alpha4beta2 nicotinic acetylcholine receptor in complex with acetylcholine and calcium
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Neuronal acetylcholine receptor subunit alpha-4 | polymer | 386 | 44862.4 | 2 | UniProt (P43681) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 2 | B, C, E (B, C, E) | Neuronal acetylcholine receptor subunit beta-2 | polymer | 403 | 46748.9 | 3 | UniProt (P17787) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | |
| 3 | F, H, J (F, H, J) | IgG1 Kappa Light Chain | polymer | 238 | 26378.6 | 3 | Mus musculus (mouse) | ||
| 4 | G, I, K (G, I, K) | IgG1 Heavy Chain | polymer | 462 | 51195.7 | 3 | Mus musculus (mouse) | ||
| 5 | L, M, N (L, M, N) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 6 | O, P, Q, V, W... (A, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 7 | R, Y (A, D) | ACETYLCHOLINE | non-polymer | 146.2 | 2 | Chemie (ACH) | |||
| 8 | S, T, Z (A, D) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 9 | U (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 10 | AA, BA, CA (B, D, E) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 338 (UniProt: P43681)
A, D: 339 - 386 (UniProt: P43681)
B, C, E: 1 - 330 (UniProt: P17787)
B, C, E: 331 - 393 (UniProt: P17787)
A, D: 339 - 386 (UniProt: P43681)
| PDB | External Database | Details |
|---|---|---|
| Glu 343 | - | insertion |
| Arg 344 | - | insertion |
B, C, E: 331 - 393 (UniProt: P17787)
| PDB | External Database | Details |
|---|---|---|
| Glu 335 | - | insertion |
| Arg 336 | - | insertion |
| Ser 394 | - | linker |
| Ala 395 | - | linker |
| Trp 396 | - | expression tag |
| Ser 397 | - | expression tag |
| His 398 | - | expression tag |
| Pro 399 | - | expression tag |
| Gln 400 | - | expression tag |
| Phe 401 | - | expression tag |
| Glu 402 | - | expression tag |
| Lys 403 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 462694.1 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1759.6 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1762.9 | |
| All* | Total formula weight | 466216.6 |
