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6S6V
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BU of 6s6v by Molmil
Resting state of the E. coli Mre11-Rad50 (SbcCD) head complex bound to ATPgS
Descriptor: MAGNESIUM ION, MANGANESE (II) ION, Nuclease SbcCD subunit C, ...
Authors:Kaeshammer, L, Saathoff, J.H, Gut, F, Bartho, J, Alt, A, Kessler, B, Lammens, K, Hopfner, K.P.
Deposit date:2019-07-03
Release date:2019-09-04
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanism of DNA End Sensing and Processing by the Mre11-Rad50 Complex.
Mol.Cell, 76, 2019
4YKE
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BU of 4yke by Molmil
Crystal structure of eukaryotic Mre11 catalytic domain from Chaetomium thermophilum
Descriptor: MANGANESE (II) ION, Mre11
Authors:Seifert, F.U, Lammens, K, Hopfner, K.-P.
Deposit date:2015-03-04
Release date:2015-06-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.783 Å)
Cite:Structure of the catalytic domain of Mre11 from Chaetomium thermophilum.
Acta Crystallogr.,Sect.F, 71, 2015
4ZX2
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BU of 4zx2 by Molmil
Co-crystal structures of PP5 in complex with 5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Descriptor: (1S,2R,3S,4R,5S)-5-methyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Chattopadhyay, D, Swingle, M.R, Salter, E.A, Wierzbicki, A, Honkanen, R.E.
Deposit date:2015-05-19
Release date:2016-04-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C.
Biochem. Pharmacol., 109, 2016
7QFB
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BU of 7qfb by Molmil
Crystal structure of Protein Phosphatase 1 in complex with PP1-binding peptide from PTG
Descriptor: GLYCEROL, MANGANESE (II) ION, Protein phosphatase 1 regulatory subunit 3C, ...
Authors:Semrau, M.S, Storici, P, Lolli, G.
Deposit date:2021-12-05
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.
Nat Commun, 13, 2022
7QM2
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BU of 7qm2 by Molmil
Crystal structure of the PP1/PTG/beta-cyclodextrin ternary complex
Descriptor: Cycloheptakis-(1-4)-(alpha-D-glucopyranose), Protein phosphatase 1 regulatory subunit 3C, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
Authors:Semrau, M.S, Storici, P, Lolli, G.
Deposit date:2021-12-20
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.685 Å)
Cite:Molecular architecture of the glycogen- committed PP1/PTG holoenzyme.
Nat Commun, 13, 2022
7QWJ
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BU of 7qwj by Molmil
Crystal structure of Glc7 phosphatase
Descriptor: MANGANESE (II) ION, PHOSPHATE ION, Serine/threonine-protein phosphatase PP1-2
Authors:Malhotra, K, Carminati, M, Bertolotti, A, Bellini, D.
Deposit date:2022-01-25
Release date:2023-02-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of Glc7 phosphatase
To Be Published
2QFR
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BU of 2qfr by Molmil
Crystal structure of red kidney bean purple acid phosphatase with bound sulfate
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, ...
Authors:Guddat, L.W, Schenk, G, Gahan, L.R, Elliot, T.W, Leung, E.
Deposit date:2007-06-27
Release date:2008-10-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle.
Bmc Struct.Biol., 8, 2008
3LL8
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BU of 3ll8 by Molmil
Crystal Structure of Calcineurin in Complex with AKAP79 Peptide
Descriptor: AKAP79 peptide, CALCIUM ION, Calcineurin subunit B type 1, ...
Authors:Li, H, Hogan, P.G.
Deposit date:2010-01-28
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Balanced interactions of calcineurin with AKAP79 regulate Ca(2+)-calcineurin-NFAT signaling.
Nat.Struct.Mol.Biol., 19, 2012
3P71
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BU of 3p71 by Molmil
Crystal structure of the complex of LCMT-1 and PP2A
Descriptor: 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, DI(HYDROXYETHYL)ETHER, Leucine carboxyl methyltransferase 1, ...
Authors:Xing, Y, Stanevich, V, Satyshur, K.A, Jiang, L.
Deposit date:2010-10-11
Release date:2011-02-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1.
Mol.Cell, 41, 2011
2QFP
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BU of 2qfp by Molmil
Crystal structure of red kidney bean purple acid phosphatase in complex with fluoride
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, FLUORIDE ION, ...
Authors:Guddat, L.W, Schenk, G.S, Gahan, L.R, Elliot, T.W, Leung, E.
Deposit date:2007-06-27
Release date:2008-10-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle.
Bmc Struct.Biol., 8, 2008
3K7V
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BU of 3k7v by Molmil
Protein phosphatase 2A core complex bound to dinophysistoxin-1
Descriptor: (2R)-3-[(2S,5R,6R,8S)-8-{(1R,2E)-3-[(2R,4a'R,5R,6'S,8'R,8a'S)-6'-{(1S,3S)-3-[(2S,3R,6R,11R)-3,11-dimethyl-1,7-dioxaspiro[5.5]undec-2-yl]-1-hydroxybutyl}-8'-hydroxy-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]-1-methylprop-2-en-1-yl}-5-hydroxy-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-hydroxy-2-methylpropanoic acid, MANGANESE (II) ION, SULFATE ION, ...
Authors:Jeffrey, P.D, Huhn, J, Shi, Y.
Deposit date:2009-10-13
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:A structural basis for the reduced toxicity of dinophysistoxin-2.
Chem.Res.Toxicol., 22, 2009
3K7W
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BU of 3k7w by Molmil
Protein phosphatase 2A core complex bound to dinophysistoxin-2
Descriptor: (2R)-2-hydroxy-3-[(2S,5R,6R,8S)-5-hydroxy-8-{(1R,2E)-3-[(2R,4a'R,5R,6'S,8'R,8a'S)-8'-hydroxy-6'-{(1S,3S)-1-hydroxy-3-[( 2S,6R,11S)-11-methyl-1,7-dioxaspiro[5.5]undec-2-yl]butyl}-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]p yran]-5-yl]-1-methylprop-2-en-1-yl}-10-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-2-methylpropanoic acid, MANGANESE (II) ION, SULFATE ION, ...
Authors:Jeffrey, P.D, Huhn, J, Shi, Y.
Deposit date:2009-10-13
Release date:2009-11-03
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:A structural basis for the reduced toxicity of dinophysistoxin-2.
Chem.Res.Toxicol., 22, 2009
2P6B
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BU of 2p6b by Molmil
Crystal Structure of Human Calcineurin in Complex with PVIVIT Peptide
Descriptor: CALCIUM ION, Calcineurin subunit B isoform 1, Calmodulin-dependent calcineurin A subunit alpha isoform, ...
Authors:Li, H, Zhang, L, Rao, A, Harrison, S.C, Hogan, P.G.
Deposit date:2007-03-16
Release date:2007-06-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of calcineurin in complex with PVIVIT peptide: Portrait of a low-affinity signalling interaction
J.Mol.Biol., 369, 2007
2USH
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BU of 2ush by Molmil
5'-NUCLEOTIDASE FROM E. COLI
Descriptor: 5'-NUCLEOTIDASE, TUNGSTATE(VI)ION, ZINC ION
Authors:Knofel, T, Strater, N.
Deposit date:1998-09-24
Release date:1999-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site.
Nat.Struct.Biol., 6, 1999
7SOY
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BU of 7soy by Molmil
The structure of the PP2A-B56gamma1 holoenzyme-PME-1 complex
Descriptor: Isoform Gamma-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Protein phosphatase methylesterase 1, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Li, Y, Balakrishnan, V.K, Rowse, M, Novikova, I.V, Xing, Y.
Deposit date:2021-11-01
Release date:2022-08-31
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
Elife, 11, 2022
2Z1A
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BU of 2z1a by Molmil
Crystal structure of 5'-nucleotidase precursor from Thermus thermophilus HB8
Descriptor: 5'-nucleotidase, PHOSPHATE ION, THYMIDINE, ...
Authors:Nakagawa, N, Kishishita, S, Yokoyama, S, Kuramitsu, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-05-08
Release date:2007-11-13
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of 5'-nucleotidase precursor from Thermus thermophilus HB8
To be Published
3KBP
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BU of 3kbp by Molmil
KIDNEY BEAN PURPLE ACID PHOSPHATASE
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, FE (III) ION, PURPLE ACID PHOSPHATASE, ...
Authors:Klabunde, T, Strater, N, Krebs, B.
Deposit date:1995-10-02
Release date:1996-12-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures.
J.Mol.Biol., 259, 1996
3N5U
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BU of 3n5u by Molmil
Crystal structure of an Rb C-terminal peptide bound to the catalytic subunit of PP1
Descriptor: CHLORIDE ION, MANGANESE (II) ION, Retinoblastoma-associated protein, ...
Authors:Hirschi, A.M, Cecchini, M, Steinhardt, R.C, Dick, F.A, Rubin, S.M.
Deposit date:2010-05-25
Release date:2010-08-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein.
Nat.Struct.Mol.Biol., 17, 2010
3QG5
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BU of 3qg5 by Molmil
The Mre11:Rad50 complex forms an ATP dependent molecular clamp in DNA double-strand break repair
Descriptor: GLYCEROL, Mre11, rad50
Authors:Lammens, K.
Deposit date:2011-01-24
Release date:2011-04-20
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Mre11:Rad50 Structure Shows an ATP-Dependent Molecular Clamp in DNA Double-Strand Break Repair.
Cell(Cambridge,Mass.), 145, 2011
2XMO
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BU of 2xmo by Molmil
The crystal structure of Lmo2642
Descriptor: CALCIUM ION, FE (III) ION, LMO2642 PROTEIN, ...
Authors:Jeong, J.H, Kim, Y.G.
Deposit date:2010-07-28
Release date:2011-02-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Functional Analysis of the Lmo2642 Cyclic Nucleotide Phosphodiesterase from Listeria Monocytogenes.
Proteins, 79, 2011
3QFK
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BU of 3qfk by Molmil
2.05 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with alpha-ketoglutarate
Descriptor: 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, DI(HYDROXYETHYL)ETHER, ...
Authors:Minasov, G, Wawrzak, Z, Krishna, S.N, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Kiryukhina, O, Bagnoli, F, Falugi, F, Bottomley, M, Grandi, G, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-01-21
Release date:2011-02-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:2.05 Angstrom Crystal Structure of Putative 5'-Nucleotidase from Staphylococcus aureus in complex with alpha-ketoglutarate.
TO BE PUBLISHED
5UKI
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BU of 5uki by Molmil
Mn2+ and Zn2+ requirements for the lariat debranching enzyme, Dbr1
Descriptor: MANGANESE (II) ION, RNA lariat debranching enzyme, putative, ...
Authors:Macbeth, M.R, Ransey, L.
Deposit date:2017-01-22
Release date:2018-02-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn2+/Mn2+heterobinucleation.
FEBS Lett., 591, 2017
5W0W
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BU of 5w0w by Molmil
Crystal structure of Protein Phosphatase 2A bound to TIPRL
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Wu, C, Zheng, A, Li, J, Satyshur, K, Xing, Y.
Deposit date:2017-06-01
Release date:2018-01-17
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Methylation-regulated decommissioning of multimeric PP2A complexes.
Nat Commun, 8, 2017
5WG8
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BU of 5wg8 by Molmil
Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density
Descriptor: (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:D'Arcy, B.M, Swingle, M.R, Honkanen, R.E, Prakash, A.
Deposit date:2017-07-13
Release date:2018-07-18
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
Mol. Cancer Ther., 18, 2019
2IAE
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BU of 2iae by Molmil
Crystal structure of a protein phosphatase 2A (PP2A) holoenzyme.
Descriptor: MANGANESE (II) ION, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, ...
Authors:Cho, U.S, Xu, W.
Deposit date:2006-09-07
Release date:2006-12-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme.
Nature, 445, 2007

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