6Z9D
Human Ecto-5'-nucleotidase (CD73) in complex with AOPCP derivative AB680 (compound 55 in publication) in the closed form (crystal form III)
Summary for 6Z9D
Entry DOI | 10.2210/pdb6z9d/pdb |
Descriptor | 5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | zinc enzyme, nucleotide analog, inhibitor, arcus biosciences, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 62452.79 |
Authors | Strater, N. (deposition date: 2020-06-03, release date: 2020-09-16, Last modification date: 2024-01-24) |
Primary citation | Lawson, K.V.,Kalisiak, J.,Lindsey, E.A.,Newcomb, E.T.,Leleti, M.R.,Debien, L.,Rosen, B.R.,Miles, D.H.,Sharif, E.U.,Jeffrey, J.L.,Tan, J.B.L.,Chen, A.,Zhao, S.,Xu, G.,Fu, L.,Jin, L.,Park, T.W.,Berry, W.,Moschutz, S.,Scaletti, E.,Strater, N.,Walker, N.P.,Young, S.W.,Walters, M.J.,Schindler, U.,Powers, J.P. Discovery of AB680: A Potent and Selective Inhibitor of CD73. J.Med.Chem., 63:11448-11468, 2020 Cited by PubMed: 32614585DOI: 10.1021/acs.jmedchem.0c00525 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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