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2BCD

X-ray crystal structure of Protein Phosphatase-1 with the marine toxin motuporin bound

Summary for 2BCD
Entry DOI10.2210/pdb2bcd/pdb
Related2BDX
Related PRD IDPRD_000213
DescriptorSerine/threonine protein phosphatase PP1-gamma catalytic subunit, MOTUPORIN, BETA-MERCAPTOETHANOL, ... (5 entities in total)
Functional Keywordsprotein phosphtase, natural product inhibitors, motuporin, nodularin, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P36873
Total number of polymer chains2
Total formula weight38412.47
Authors
Maynes, J.T.,Luu, H.A.,Cherney, M.M.,Andersen, R.J.,Williams, D.,Holmes, C.F.,James, M.N. (deposition date: 2005-10-19, release date: 2006-01-17, Last modification date: 2023-11-15)
Primary citationMaynes, J.T.,Luu, H.A.,Cherney, M.M.,Andersen, R.J.,Williams, D.,Holmes, C.F.,James, M.N.
Crystal Structures of Protein Phosphatase-1 Bound to Motuporin and Dihydromicrocystin-LA: Elucidation of the Mechanism of Enzyme Inhibition by Cyanobacterial Toxins.
J.Mol.Biol., 356:111-120, 2006
Cited by
PubMed: 16343532
DOI: 10.1016/j.jmb.2005.11.019
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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