2BDX

X-ray Crystal Structure of dihydromicrocystin-LA bound to Protein Phosphatase-1

Summary for 2BDX

• Entry DOI: 10.2210/pdb2bdx/pdb
• Related: 2BCD
• Related PRD ID: PRD_000215
• Descriptor: Serine/threonine protein phosphatase PP1-gamma catalytic subunit, DIHYDROMICROCYSTIN-LA, MANGANESE (II) ION, ... (4 entities in total)
• Functional Keywords: protein phosphatase, natural product inhibitors, microcystins, nodularins, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P36873
• Total number of polymer chains: 2
• Total formula weight: 38070.75

Authors

Maynes, J.T.,Luu, H.A.,Cherney, M.M.,Andersen, R.J.,Williams, D.,Holmes, C.F.,James, M.N. (deposition date: 2005-10-21, release date: 2006-01-17, Last modification date: 2023-11-15)

• Primary citation: Maynes, J.T.,Luu, H.A.,Cherney, M.M.,Andersen, R.J.,Williams, D.,Holmes, C.F.,James, M.N.; Crystal Structures of Protein Phosphatase-1 Bound to Motuporin and Dihydromicrocystin-LA: Elucidation of the Mechanism of Enzyme Inhibition by Cyanobacterial Toxins.; J.Mol.Biol., 356:111-120, 2006; PubMed: 16343532; DOI: 10.1016/j.jmb.2005.11.019

Experimental method

X-RAY DIFFRACTION (2.3 Å)