6MOJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6moj by Molmil](/molmil-images/mine/6moj) | Dimeric DARPin A_angle_R5 complex with EpoR | Descriptor: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | Authors: | Jude, K.M, Mohan, K, Garcia, K.C. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.431 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
|
|
6MOK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mok by Molmil](/molmil-images/mine/6mok) | Dimeric DARPin A_distance_R7 complex with EpoR | Descriptor: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | Authors: | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | Deposit date: | 2018-10-04 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (5.101 Å) | Cite: | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
|
|
6HN4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hn4 by Molmil](/molmil-images/mine/6hn4) | Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor,Insulin receptor,General control protein GCN4 | Authors: | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | Deposit date: | 2018-09-14 | Release date: | 2018-11-21 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9, 2018
|
|
6HNF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hnf by Molmil](/molmil-images/mine/6hnf) | Structure in solution of human fibronectin type III-domain 14 | Descriptor: | Fibronectin | Authors: | Zhong, X, Arnolds, O, Krenczyk, O, Gajewski, J, Puetz, S, Herrmann, C, Stoll, R. | Deposit date: | 2018-09-14 | Release date: | 2018-10-10 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | The Structure in Solution of Fibronectin Type III Domain 14 Reveals Its Synergistic Heparin Binding Site. Biochemistry, 57, 2018
|
|
6HN5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6hn5 by Molmil](/molmil-images/mine/6hn5) | Leucine-zippered human insulin receptor ectodomain with single bound insulin - "upper" membrane-distal part | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin, ... | Authors: | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | Deposit date: | 2018-09-14 | Release date: | 2018-11-21 | Last modified: | 2022-03-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The signalling conformation of the insulin receptor ectodomain. Nat Commun, 9, 2018
|
|
6MFA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mfa by Molmil](/molmil-images/mine/6mfa) | |
6GVL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gvl by Molmil](/molmil-images/mine/6gvl) | Second pair of Fibronectin type III domains of integrin beta4 bound to the bullous pemphigoid antigen BP230 (BPAG1e) | Descriptor: | Dystonin, Integrin beta-4 | Authors: | Manso, J.A, Gomez-Hernandez, M, Alonso-Garcia, N, de Pereda, J.M. | Deposit date: | 2018-06-21 | Release date: | 2019-03-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Integrin alpha 6 beta 4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure, 27, 2019
|
|
6GVK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6gvk by Molmil](/molmil-images/mine/6gvk) | Second pair of Fibronectin type III domains of integrin beta4 (T1663R mutant) bound to the bullous pemphigoid antigen BP230 (BPAG1e) | Descriptor: | Dystonin, GLYCEROL, Integrin beta-4 | Authors: | Manso, J.A, Gomez-Hernandez, M, Alonso-Garcia, N, de Pereda, J.M. | Deposit date: | 2018-06-21 | Release date: | 2019-03-20 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Integrin alpha 6 beta 4 Recognition of a Linear Motif of Bullous Pemphigoid Antigen BP230 Controls Its Recruitment to Hemidesmosomes. Structure, 27, 2019
|
|
6CE9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ce9 by Molmil](/molmil-images/mine/6ce9) | Insulin Receptor ectodomain in complex with two insulin molecules | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | Deposit date: | 2018-02-11 | Release date: | 2018-03-14 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
|
|
6CEB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ceb by Molmil](/molmil-images/mine/6ceb) | Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | Deposit date: | 2018-02-11 | Release date: | 2018-03-14 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
|
|
6CE7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6ce7 by Molmil](/molmil-images/mine/6ce7) | Insulin Receptor ectodomain in complex with one insulin molecule | Descriptor: | Insulin A chain, Insulin B chain, Insulin receptor, ... | Authors: | Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B. | Deposit date: | 2018-02-11 | Release date: | 2018-03-14 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (7.4 Å) | Cite: | Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis. Nature, 556, 2018
|
|
6BRB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6brb by Molmil](/molmil-images/mine/6brb) | Novel non-antibody protein scaffold targeting CD40L | Descriptor: | CD40 ligand, Tn3-like, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Oganesyan, V, Baca, M, Thisted, T, Grinberg, L, Wu, H, Dall'Acqua, W.F. | Deposit date: | 2017-11-30 | Release date: | 2018-12-05 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity. Sci Transl Med, 11, 2019
|
|
5XWT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5xwt by Molmil](/molmil-images/mine/5xwt) | Crystal structure of PTPdelta Ig1-Fn1 in complex with SALM5 LRR-Ig | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Goto-Ito, S, Yamagata, A, Sato, Y, Fukai, S. | Deposit date: | 2017-06-30 | Release date: | 2018-06-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (4.178 Å) | Cite: | Structural basis of trans-synaptic interactions between PTP delta and SALMs for inducing synapse formation. Nat Commun, 9, 2018
|
|
5X83
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5x83 by Molmil](/molmil-images/mine/5x83) | Structure of DCC FN456 domains | Descriptor: | Netrin receptor DCC | Authors: | Finci, F.I, Xiao, J, Wang, J. | Deposit date: | 2017-02-28 | Release date: | 2017-09-06 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.997 Å) | Cite: | Structure of unliganded membrane-proximal domains FN4-FN5-FN6 of DCC Protein Cell, 8, 2017
|
|
5UTK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5utk by Molmil](/molmil-images/mine/5utk) | |
5N48
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5n48 by Molmil](/molmil-images/mine/5n48) | |
5N47
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5n47 by Molmil](/molmil-images/mine/5n47) | |
5N06
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5n06 by Molmil](/molmil-images/mine/5n06) | |
5MYB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5myb by Molmil](/molmil-images/mine/5myb) | Homodimerization of Tie2 Fibronectin-like domains 2 and 3 in space group P21 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ... | Authors: | Leppanen, V.-M, Saharinen, P, Alitalo, K. | Deposit date: | 2017-01-26 | Release date: | 2017-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5MYA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5mya by Molmil](/molmil-images/mine/5mya) | Homodimerization of Tie2 Fibronectin-like domains 1-3 in space group C2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ... | Authors: | Leppanen, V.-M, Saharinen, P, Alitalo, K. | Deposit date: | 2017-01-26 | Release date: | 2017-04-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5U8R
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5u8r by Molmil](/molmil-images/mine/5u8r) | |
5U8Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5u8q by Molmil](/molmil-images/mine/5u8q) | |
5M0A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5m0a by Molmil](/molmil-images/mine/5m0a) | |
5LKN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5lkn by Molmil](/molmil-images/mine/5lkn) | NMR solution structure of human FNIII domain 2 of NCAM | Descriptor: | Neural cell adhesion molecule 1 | Authors: | Slapsak, U, Salzano, G, Amin, L, Abskharon, R.N.N, Ilc, G, Zupancic, B, Biljan, I, Plavec, J, Giachin, G, Legname, G. | Deposit date: | 2016-07-22 | Release date: | 2016-09-14 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain. J.Biol.Chem., 291, 2016
|
|
5KF4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5kf4 by Molmil](/molmil-images/mine/5kf4) | |