6DDE
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![BU of 6dde by Molmil](/molmil-images/mine/6dde) | Mu Opioid Receptor-Gi Protein Complex | Descriptor: | DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I. | Deposit date: | 2018-05-10 | Release date: | 2018-06-13 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the mu-opioid receptor-Giprotein complex. Nature, 558, 2018
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6DQQ
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5LCJ
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![BU of 5lcj by Molmil](/molmil-images/mine/5lcj) | In-Gel Activity-Based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor | Descriptor: | Mitogen-activated protein kinase 1, SULFATE ION, [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[5-chloranyl-4-[[2-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate | Authors: | O'Reilly, M, Wright, D. | Deposit date: | 2016-06-22 | Release date: | 2016-07-20 | Last modified: | 2016-08-31 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor. Mol Biosyst, 12, 2016
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6DSY
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![BU of 6dsy by Molmil](/molmil-images/mine/6dsy) | Bst DNA polymerase I post-chemistry (n+1) structure | Descriptor: | DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ... | Authors: | Chim, N, Jackson, L.N, Chaput, J.C. | Deposit date: | 2018-06-14 | Release date: | 2018-10-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway. Elife, 7, 2018
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6DWO
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6DJR
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5LCK
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![BU of 5lck by Molmil](/molmil-images/mine/5lck) | A Clickable Covalent ERK 1/2 Inhibitor | Descriptor: | Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-[2-[[2-[(5-methoxypyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]propanamide | Authors: | O'Reilly, M, Wright, D. | Deposit date: | 2016-06-22 | Release date: | 2016-07-20 | Last modified: | 2018-03-28 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor. Mol Biosyst, 12, 2016
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6DL8
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6DM9
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![BU of 6dm9 by Molmil](/molmil-images/mine/6dm9) | DHD15_extended | Descriptor: | DHD15_extended_A, DHD15_extended_B, SULFATE ION | Authors: | Bick, M.J, Chen, Z, Baker, D. | Deposit date: | 2018-06-04 | Release date: | 2018-12-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
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6DQ7
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6DC1
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![BU of 6dc1 by Molmil](/molmil-images/mine/6dc1) | Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7 | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-nitro-2-oxidanyl-benzenecarbonitrile, ... | Authors: | Jackson, C.J, Hong, N.-S, Carr, P.D. | Deposit date: | 2018-05-03 | Release date: | 2018-08-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | The evolution of multiple active site configurations in a designed enzyme. Nat Commun, 9, 2018
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6DVI
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5LF2
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![BU of 5lf2 by Molmil](/molmil-images/mine/5lf2) | Crystal structure of laminin beta2 LE5-LF-LE6 | Descriptor: | CALCIUM ION, CHLORIDE ION, Laminin subunit beta-2 | Authors: | Pulido, D, Hohenester, E. | Deposit date: | 2016-06-30 | Release date: | 2016-07-27 | Last modified: | 2017-03-08 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Crystallographic analysis of the laminin beta 2 short arm reveals how the LF domain is inserted into a regular array of LE domains. Matrix Biol., 57-58, 2017
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6DGL
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6DHN
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![BU of 6dhn by Molmil](/molmil-images/mine/6dhn) | Bovine glutamate dehydrogenase complexed with Eu3+ | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Smith, T.J. | Deposit date: | 2018-05-20 | Release date: | 2018-07-25 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis. FEBS J., 278, 2011
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6D9S
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![BU of 6d9s by Molmil](/molmil-images/mine/6d9s) | The (p)ppGpp-bound crystal structure of HPRT (hypoxanthine phosphoribosyltransferase) | Descriptor: | DI(HYDROXYETHYL)ETHER, GUANOSINE-5',3'-TETRAPHOSPHATE, Hypoxanthine phosphoribosyltransferase, ... | Authors: | Satyshur, K.A, Dubiel, K, Anderson, B, Wolak, C, Keck, J.L. | Deposit date: | 2018-04-30 | Release date: | 2019-05-01 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.105 Å) | Cite: | Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction. Elife, 8, 2019
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6DNJ
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![BU of 6dnj by Molmil](/molmil-images/mine/6dnj) | Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 28 round 5 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-nitro-1,2-benzoxazole, Kemp eliminase KE07 | Authors: | Jackson, C.J, Hong, N.-S, Carr, P.D. | Deposit date: | 2018-06-06 | Release date: | 2018-08-01 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The evolution of multiple active site configurations in a designed enzyme. Nat Commun, 9, 2018
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6DBO
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![BU of 6dbo by Molmil](/molmil-images/mine/6dbo) | Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs | Descriptor: | CALCIUM ION, Forward strand of substrate RSS DNA, Recombination activating gene 1 - MBP chimera, ... | Authors: | Wu, H, Liao, M, Ru, H, Mi, W. | Deposit date: | 2018-05-03 | Release date: | 2018-08-01 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | DNA melting initiates the RAG catalytic pathway. Nat. Struct. Mol. Biol., 25, 2018
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5LP3
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5LNG
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![BU of 5lng by Molmil](/molmil-images/mine/5lng) | Lectin domain of E. coli F9 pilus adhesin FmlH | Descriptor: | Putative Fml fimbrial adhesin FmlD, SULFATE ION | Authors: | Ruer, S, Conover, M.S, Kalas, V, Taganna, J, De Greve, H, Pinkner, J.S, Dodson, K.W, Hultgren, S.J, Remaut, H. | Deposit date: | 2016-08-04 | Release date: | 2016-10-05 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection. Cell Host Microbe, 20, 2016
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6DS6
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6DF8
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![BU of 6df8 by Molmil](/molmil-images/mine/6df8) | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with the specific Kaiso binding sequence (KBS), pH 6.5 | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), ... | Authors: | Nikolova, E.N, Stanfield, R.L, Dyson, H.J, Wright, P.E. | Deposit date: | 2018-05-14 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.536 Å) | Cite: | A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences. Biochemistry, 2020
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6DSL
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![BU of 6dsl by Molmil](/molmil-images/mine/6dsl) | Consensus engineered intein (Cat) with atypical split site | Descriptor: | Consensus engineered intein CatC, Consensus engineered intein CatN | Authors: | Sekar, G, Stevens, A.J, Muir, T.W, Cowburn, D. | Deposit date: | 2018-06-14 | Release date: | 2018-09-19 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | An Atypical Mechanism of Split Intein Molecular Recognition and Folding. J. Am. Chem. Soc., 140, 2018
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6DGR
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6DUW
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![BU of 6duw by Molmil](/molmil-images/mine/6duw) | |