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6DDE
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BU of 6dde by Molmil
Mu Opioid Receptor-Gi Protein Complex
Descriptor: DAMGO, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Koehl, A, Hu, H, Maeda, S, Manglik, A, Zhang, Y, Kobilka, B.K, Skiniotis, G, Weis, W.I.
Deposit date:2018-05-10
Release date:2018-06-13
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of the mu-opioid receptor-Giprotein complex.
Nature, 558, 2018
6DQQ
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BU of 6dqq by Molmil
Crystal structure of Haemophilus influenzae OppA complex with endogenous peptide
Descriptor: ACETATE ION, ALA-ALA-ALA-ALA, Periplasmic oligopeptide-binding protein, ...
Authors:Tanaka, K.J, Pinkett, H.W.
Deposit date:2018-06-11
Release date:2018-11-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Oligopeptide-binding protein from nontypeableHaemophilus influenzaehas ligand-specific sites to accommodate peptides and heme in the binding pocket.
J. Biol. Chem., 294, 2019
5LCJ
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BU of 5lcj by Molmil
In-Gel Activity-Based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION, [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[5-chloranyl-4-[[2-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate
Authors:O'Reilly, M, Wright, D.
Deposit date:2016-06-22
Release date:2016-07-20
Last modified:2016-08-31
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor.
Mol Biosyst, 12, 2016
6DSY
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BU of 6dsy by Molmil
Bst DNA polymerase I post-chemistry (n+1) structure
Descriptor: DNA (5'-D(*GP*CP*GP*AP*TP*CP*AP*CP*GP*T)-3'), DNA (5'-D(P*GP*TP*AP*CP*GP*TP*GP*AP*TP*CP*GP*CP*A)-3'), DNA polymerase I, ...
Authors:Chim, N, Jackson, L.N, Chaput, J.C.
Deposit date:2018-06-14
Release date:2018-10-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway.
Elife, 7, 2018
6DWO
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BU of 6dwo by Molmil
Crystal structure of alpha-1-2-mannosidase from Enterococcus faecalis V583
Descriptor: ACETATE ION, Alpha-1,2-mannosidase, CALCIUM ION, ...
Authors:Fisher, A.J, Li, Y.
Deposit date:2018-06-26
Release date:2019-10-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Enterococcus faecalis alpha 1-2-mannosidase (EfMan-I): an efficient catalyst for glycoprotein N-glycan modification.
Febs Lett., 594, 2020
6DJR
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BU of 6djr by Molmil
Full-length human TRPC3 in GDN
Descriptor: Transient Receptor Potential Cation Channel Subfamily C Member 3
Authors:Sierra-Valdez, F.J, Azumaya, C.M, Nakagawa, T, Cordero-Morales, J.F.
Deposit date:2018-05-26
Release date:2018-08-29
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structure-function analyses of the ion channel TRPC3 reveal that its cytoplasmic domain allosterically modulates channel gating.
J. Biol. Chem., 293, 2018
5LCK
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BU of 5lck by Molmil
A Clickable Covalent ERK 1/2 Inhibitor
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-[2-[[2-[(5-methoxypyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]propanamide
Authors:O'Reilly, M, Wright, D.
Deposit date:2016-06-22
Release date:2016-07-20
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor.
Mol Biosyst, 12, 2016
6DL8
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BU of 6dl8 by Molmil
Crystal Structure of an influenza A hemagglutinin antibody Fab variant CH67:1203d4 chimera
Descriptor: CH67:1203d4 FAB light chain, Ch67:1203d4 FAB heavy chain
Authors:Dong, J, Finn, J.A, Crowe, J.E.
Deposit date:2018-05-31
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.805 Å)
Cite:Identification of Structurally Related Antibodies in Antibody Sequence Databases Using Rosetta-Derived Position-Specific Scoring.
Structure, 28, 2020
6DM9
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BU of 6dm9 by Molmil
DHD15_extended
Descriptor: DHD15_extended_A, DHD15_extended_B, SULFATE ION
Authors:Bick, M.J, Chen, Z, Baker, D.
Deposit date:2018-06-04
Release date:2018-12-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Programmable design of orthogonal protein heterodimers.
Nature, 565, 2019
6DQ7
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BU of 6dq7 by Molmil
LINKED KDM5A JMJ DOMAIN BOUND TO THE POTENTIAL HYDROLYSIS PRODUCT OF INHIBITOR N45 i.e. 3-((6-(4-(2-cyano-3-methylbut-2-enoyl)-1,4-diazepan-1-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoic acid
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Linked KDM5A Jmj Domain, ...
Authors:Horton, J.R, Cheng, X.
Deposit date:2018-06-10
Release date:2019-06-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.852 Å)
Cite:Structure-based Engineering of Reversible Covalent Inhibitors Against Histone Lysine Demethylase 5A
To Be Published
6DC1
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BU of 6dc1 by Molmil
Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-nitro-2-oxidanyl-benzenecarbonitrile, ...
Authors:Jackson, C.J, Hong, N.-S, Carr, P.D.
Deposit date:2018-05-03
Release date:2018-08-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9, 2018
6DVI
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BU of 6dvi by Molmil
Wild-type Lactate Monooxygenase from Mycobacterium smegmatis
Descriptor: FLAVIN MONONUCLEOTIDE, Lactate 2-monooxygenase, SULFATE ION
Authors:Kean, K.M, Karplus, P.A.
Deposit date:2018-06-23
Release date:2018-10-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and role for active site lid of lactate monooxygenase from Mycobacterium smegmatis.
Protein Sci., 28, 2019
5LF2
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BU of 5lf2 by Molmil
Crystal structure of laminin beta2 LE5-LF-LE6
Descriptor: CALCIUM ION, CHLORIDE ION, Laminin subunit beta-2
Authors:Pulido, D, Hohenester, E.
Deposit date:2016-06-30
Release date:2016-07-27
Last modified:2017-03-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystallographic analysis of the laminin beta 2 short arm reveals how the LF domain is inserted into a regular array of LE domains.
Matrix Biol., 57-58, 2017
6DGL
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BU of 6dgl by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Darglitazone
Descriptor: (5Z)-5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methylidene)-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2018-05-17
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Quantitative structural assessment of graded receptor agonism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6DHN
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BU of 6dhn by Molmil
Bovine glutamate dehydrogenase complexed with Eu3+
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, GLUTAMIC ACID, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Smith, T.J.
Deposit date:2018-05-20
Release date:2018-07-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A novel mechanism of V-type zinc inhibition of glutamate dehydrogenase results from disruption of subunit interactions necessary for efficient catalysis.
FEBS J., 278, 2011
6D9S
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BU of 6d9s by Molmil
The (p)ppGpp-bound crystal structure of HPRT (hypoxanthine phosphoribosyltransferase)
Descriptor: DI(HYDROXYETHYL)ETHER, GUANOSINE-5',3'-TETRAPHOSPHATE, Hypoxanthine phosphoribosyltransferase, ...
Authors:Satyshur, K.A, Dubiel, K, Anderson, B, Wolak, C, Keck, J.L.
Deposit date:2018-04-30
Release date:2019-05-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Evolution of (p)ppGpp-HPRT regulation through diversification of an allosteric oligomeric interaction.
Elife, 8, 2019
6DNJ
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BU of 6dnj by Molmil
Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 28 round 5
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 5-nitro-1,2-benzoxazole, Kemp eliminase KE07
Authors:Jackson, C.J, Hong, N.-S, Carr, P.D.
Deposit date:2018-06-06
Release date:2018-08-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9, 2018
6DBO
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BU of 6dbo by Molmil
Cryo-EM structure of RAG in complex with 12-RSS and 23-RSS substrate DNAs
Descriptor: CALCIUM ION, Forward strand of substrate RSS DNA, Recombination activating gene 1 - MBP chimera, ...
Authors:Wu, H, Liao, M, Ru, H, Mi, W.
Deposit date:2018-05-03
Release date:2018-08-01
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.4 Å)
Cite:DNA melting initiates the RAG catalytic pathway.
Nat. Struct. Mol. Biol., 25, 2018
5LP3
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BU of 5lp3 by Molmil
Three tetrameric rings of Isoaspartyl Dipeptidase fitted in an EM volume.
Descriptor: Isoaspartyl dipeptidase
Authors:Garcia-Seisdedos, H, Empereur-Mot, C, Elad, N, Levy, E.D.
Deposit date:2016-08-11
Release date:2017-07-26
Last modified:2017-08-23
Method:ELECTRON MICROSCOPY (10.5 Å)
Cite:Proteins evolve on the edge of supramolecular self-assembly.
Nature, 548, 2017
5LNG
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BU of 5lng by Molmil
Lectin domain of E. coli F9 pilus adhesin FmlH
Descriptor: Putative Fml fimbrial adhesin FmlD, SULFATE ION
Authors:Ruer, S, Conover, M.S, Kalas, V, Taganna, J, De Greve, H, Pinkner, J.S, Dodson, K.W, Hultgren, S.J, Remaut, H.
Deposit date:2016-08-04
Release date:2016-10-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.
Cell Host Microbe, 20, 2016
6DS6
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BU of 6ds6 by Molmil
Crystal structure of p300 ZZ domain in complex with histone H3 peptide
Descriptor: CHLORIDE ION, Histone H3 peptide-Histone acetyltransferase p300 Chimeric protein, ZINC ION
Authors:Zhang, Y, Kutateladze, T.G.
Deposit date:2018-06-13
Release date:2018-08-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The ZZ domain of p300 mediates specificity of the adjacent HAT domain for histone H3.
Nat. Struct. Mol. Biol., 25, 2018
6DF8
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BU of 6df8 by Molmil
Kaiso (ZBTB33) zinc finger DNA binding domain in complex with the specific Kaiso binding sequence (KBS), pH 6.5
Descriptor: CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), ...
Authors:Nikolova, E.N, Stanfield, R.L, Dyson, H.J, Wright, P.E.
Deposit date:2018-05-14
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.536 Å)
Cite:A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences.
Biochemistry, 2020
6DSL
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BU of 6dsl by Molmil
Consensus engineered intein (Cat) with atypical split site
Descriptor: Consensus engineered intein CatC, Consensus engineered intein CatN
Authors:Sekar, G, Stevens, A.J, Muir, T.W, Cowburn, D.
Deposit date:2018-06-14
Release date:2018-09-19
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:An Atypical Mechanism of Split Intein Molecular Recognition and Folding.
J. Am. Chem. Soc., 140, 2018
6DGR
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BU of 6dgr by Molmil
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with CAY10638
Descriptor: (5Z)-5-({4-[2-(thiophen-2-yl)ethoxy]phenyl}methylidene)-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma
Authors:Shang, J, Kojetin, D.J.
Deposit date:2018-05-18
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Quantitative structural assessment of graded receptor agonism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6DUW
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BU of 6duw by Molmil
Crystal structure of the alpha-N-catenin actin-binding domain H1 mutant
Descriptor: Catenin alpha-2
Authors:Ishiyama, N, Ikura, M.
Deposit date:2018-06-22
Release date:2018-12-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Force-dependent allostery of the alpha-catenin actin-binding domain controls adherens junction dynamics and functions.
Nat Commun, 9, 2018

223790

数据于2024-08-14公开中

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