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6DC1

Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7

Summary for 6DC1
Entry DOI10.2210/pdb6dc1/pdb
DescriptorKemp eliminase KE07, 5-nitro-2-oxidanyl-benzenecarbonitrile, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total)
Functional Keywordskemp eliminase, directed evolution, ke07, de novo protein, lyase
Biological sourcesynthetic construct
Total number of polymer chains12
Total formula weight351754.60
Authors
Jackson, C.J.,Hong, N.-S.,Carr, P.D. (deposition date: 2018-05-03, release date: 2018-08-01, Last modification date: 2023-10-04)
Primary citationHong, N.S.,Petrovic, D.,Lee, R.,Gryn'ova, G.,Purg, M.,Saunders, J.,Bauer, P.,Carr, P.D.,Lin, C.Y.,Mabbitt, P.D.,Zhang, W.,Altamore, T.,Easton, C.,Coote, M.L.,Kamerlin, S.C.L.,Jackson, C.J.
The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9:3900-3900, 2018
Cited by
PubMed: 30254369
DOI: 10.1038/s41467-018-06305-y
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.68 Å)
Structure validation

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