5LCK
A Clickable Covalent ERK 1/2 Inhibitor
Summary for 5LCK
Entry DOI | 10.2210/pdb5lck/pdb |
Descriptor | Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-[2-[[2-[(5-methoxypyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]propanamide, ... (4 entities in total) |
Functional Keywords | erk2 covalent inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P28482 |
Total number of polymer chains | 1 |
Total formula weight | 42413.54 |
Authors | O'Reilly, M.,Wright, D. (deposition date: 2016-06-22, release date: 2016-07-20, Last modification date: 2018-03-28) |
Primary citation | Lebraud, H.,Wright, D.J.,East, C.E.,Holding, F.P.,O'Reilly, M.,Heightman, T.D. In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor. Mol Biosyst, 12:2867-2874, 2016 Cited by PubMed: 27385078DOI: 10.1039/c6mb00367b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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