5LCJ

In-Gel Activity-Based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor

Summary for 5LCJ

Entry DOI	10.2210/pdb5lcj/pdb
Descriptor	Mitogen-activated protein kinase 1, [(1~{R},4~{Z})-cyclooct-4-en-1-yl] ~{N}-[4-[4-[[5-chloranyl-4-[[2-(propanoylamino)phenyl]amino]pyrimidin-2-yl]amino]pyridin-2-yl]but-3-ynyl]carbamate, SULFATE ION, ... (4 entities in total)
Functional Keywords	erk1/2 covalent inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains	1
Total formula weight	43332.15
Authors	O'Reilly, M.,Wright, D. (deposition date: 2016-06-22, release date: 2016-07-20, Last modification date: 2016-08-31)
Primary citation	Lebraud, H.,Wright, D.J.,East, C.E.,Holding, F.P.,O'Reilly, M.,Heightman, T.D. In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor. Mol Biosyst, 12:2867-2874, 2016 Cited by PubMed: 27385078 DOI: 10.1039/c6mb00367b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation