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1FQV
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BU of 1fqv by Molmil
Insights into scf ubiquitin ligases from the structure of the skp1-skp2 complex
Descriptor: SKP1, SKP2
Authors:Schulman, B.A, Carrano, A.C, Jeffrey, P.D, Bowen, Z, Kinnucan, E.R, Finnin, M.S, Elledge, S.J, Harper, J.W, Pagano, M, Pavletich, N.P.
Deposit date:2000-09-06
Release date:2000-11-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex.
Nature, 408, 2000
5X6U
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BU of 5x6u by Molmil
Crystal structure of human heteropentameric complex
Descriptor: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ...
Authors:Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M.
Deposit date:2017-02-23
Release date:2017-12-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the assembly of the Ragulator-Rag GTPase complex.
Nat Commun, 8, 2017
6Y85
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BU of 6y85 by Molmil
Fragment KCL_1410 in complex with MAP kinase p38-alpha
Descriptor: 1-(1-adamantylmethyl)guanidine, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, ...
Authors:De Nicola, G.F, Nichols, C.E.
Deposit date:2020-03-03
Release date:2020-03-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Fragment KCL_1410 in complex with MAP kinase p38-alpha
To Be Published
6Y8O
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BU of 6y8o by Molmil
Mycobacterium smegmatis GyrB 22kDa ATPase sub-domain in complex with novobiocin
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA gyrase subunit B, ...
Authors:Henderson, S.R, Stevenson, C.E.M, Malone, B, Zholnerovych, Y, Mitchenall, L.A, Pichowicz, M, McGarry, D.H, Cooper, I.R, Charrier, C, Salisbury, A, Lawson, D.M, Maxwell, A.
Deposit date:2020-03-05
Release date:2020-08-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase.
J.Antimicrob.Chemother., 75, 2020
7Q3K
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BU of 7q3k by Molmil
Computationally designed thioredoxin subjected to stability optimizing mutations.
Descriptor: SULFATE ION, eMM9
Authors:Norrild, R.K, Johansson, K.E, O'Shea, C, Lindorff-Larsen, K, Winther, J.R, Morth, J.P.
Deposit date:2021-10-27
Release date:2022-11-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Increasing protein stability by inferring substitution effects from high-throughput experiments.
Cell Rep Methods, 2, 2022
5U2B
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BU of 5u2b by Molmil
Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol, without a coactivator peptide
Descriptor: (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-phenylazanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol, Estrogen receptor
Authors:Nwachukwu, J.C, Nowak, J, Carlson, K.E, Katzenellenbogen, J.A, Nettles, K.W.
Deposit date:2016-11-30
Release date:2017-04-26
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.
Mol. Cell, 65, 2017
3J89
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BU of 3j89 by Molmil
Structural Plasticity of Helical Nanotubes Based on Coiled-Coil Assemblies
Descriptor: synthetic peptide
Authors:Egelman, E.H, Xu, C, DiMaio, F, Magnotti, E, Modlin, C, Yu, X, Wright, E, Baker, D, Conticello, V.P.
Deposit date:2014-10-07
Release date:2015-02-11
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural plasticity of helical nanotubes based on coiled-coil assemblies.
Structure, 23, 2015
5CC1
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BU of 5cc1 by Molmil
S425G Glucocorticoid receptor DNA binding domain - (+)GRE complex
Descriptor: DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H, Weikum, E.A, Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
1FM9
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BU of 1fm9 by Molmil
THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.
Descriptor: (9cis)-retinoic acid, 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA, ...
Authors:Gampe Jr, R.T, Montana, V.G, Lambert, M.H, Miller, A.B, Bledsoe, R.K, Milburn, M.V, Kliewer, S.A, Willson, T.M, Xu, H.E.
Deposit date:2000-08-16
Release date:2001-02-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Asymmetry in the PPARgamma/RXRalpha crystal structure reveals the molecular basis of heterodimerization among nuclear receptors.
Mol.Cell, 5, 2000
5J6S
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BU of 5j6s by Molmil
Crystal structure of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in complex with a hydroxamic derivative ligand
Descriptor: (2S)-N~1~-benzyl-2-[(4-fluorophenyl)methyl]-N~3~-hydroxypropanediamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Saridakis, E, Giastas, P, Mpakali, A, Deprez-Poulain, R, Stratikos, E.
Deposit date:2016-04-05
Release date:2017-03-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.
ACS Med Chem Lett, 8, 2017
5EUJ
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BU of 5euj by Molmil
PYRUVATE DECARBOXYLASE FROM ZYMOBACTER PALMAE
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, Pyruvate decarboxylase, ...
Authors:Buddrus, L, Crennell, S.J, Leak, D.J, Danson, M.J, Andrews, E.S.V, Arcus, V.L.
Deposit date:2015-11-18
Release date:2016-09-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of pyruvate decarboxylase from Zymobacter palmae.
Acta Crystallogr.,Sect.F, 72, 2016
6EHJ
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BU of 6ehj by Molmil
Human N-myristoyltransferase (NMT1) with Myristoyl-CoA and peptide bound
Descriptor: ASPARAGINE, COENZYME A, GLYCEROL, ...
Authors:Perez-Dorado, I, Ritzefeld, M, Tate, E.W.
Deposit date:2017-09-13
Release date:2019-03-27
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Nat Commun, 11, 2020
5UBO
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BU of 5ubo by Molmil
Mical-oxidized Actin complex with Gelsolin Segment 1
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Grintsevich, E.E, Sawaya, M.R, Reisler, E.
Deposit date:2016-12-21
Release date:2017-12-20
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Catastrophic disassembly of actin filaments via Mical-mediated oxidation.
Nat Commun, 8, 2017
6Y7Z
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BU of 6y7z by Molmil
Fragment KCL_914 in complex with MAP kinase p38-alpha
Descriptor: 1-(1-adamantyl)-3-ethyl-guanidine, 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(2-AMINO-4-PYRIMIDINYL)-IMIDAZOLE, CALCIUM ION, ...
Authors:De Nicola, G.F, Nichols, C.E.
Deposit date:2020-03-02
Release date:2020-03-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Fragment KCL_914 in complex with MAP kinase p38-alpha
To Be Published
1FQ6
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BU of 1fq6 by Molmil
X-RAY STRUCTURE OF GLYCOL INHIBITOR PD-133,450 BOUND TO SACCHAROPEPSIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(1S)-2-{[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino}-1-(ethylsulfanyl)-2-oxoethyl]-Nalpha-(morp holin-4-ylsulfonyl)-L-phenylalaninamide, SACCHAROPEPSIN, ...
Authors:Cronin, N.B, Badasso, M.O, Tickle, I.J, Dreyer, T, Hoover, D.J, Rosati, R.L, Humblet, C.C, Lunney, E.A, Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
2RVH
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BU of 2rvh by Molmil
NMR structure of eIF1
Descriptor: Eukaryotic translation initiation factor eIF-1
Authors:Nagata, T, Obayashi, E, Asano, K.
Deposit date:2015-10-16
Release date:2016-10-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5
Cell Rep, 18, 2017
5F34
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BU of 5f34 by Molmil
Crystal structure of membrane associated PatA from Mycobacterium smegmatis in complex with S-hexadecyl Coenzyme A - P21 space group
Descriptor: Phosphatidylinositol mannoside acyltransferase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{S})-4-[[3-(2-hexadecylsulfanylethylamino)-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate
Authors:Albesa-Jove, D, Svetlikova, Z, Carreras-Gonzalez, A, Tersa, M, Sancho-Vaello, E, Cifuente, J.O, Mikusova, K, Guerin, M.E.
Deposit date:2015-12-02
Release date:2016-03-09
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.281 Å)
Cite:Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA.
Nat Commun, 7, 2016
6Y3G
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BU of 6y3g by Molmil
Crystal structure of phenylalanine tRNA from Escherichia coli
Descriptor: CALCIUM ION, GLYCEROL, GUANIDINE, ...
Authors:Bourgeois, G, Mechulam, Y, Schmitt, E.
Deposit date:2020-02-18
Release date:2020-12-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of the interaction between cyclodipeptide synthases and aminoacylated tRNA substrates.
Rna, 26, 2020
8PZQ
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BU of 8pzq by Molmil
Model for focused reconstruction of influenza A RNP-like particle
Descriptor: Nucleoprotein, RNA (5'P-(UC)6-FAM3')
Authors:Chenavier, F, Estrozi, L.F, Zarkadas, E, Ruigrok, R.W.H, Schoehn, G, Ballandras-Colas, A, Crepin, T.
Deposit date:2023-07-27
Release date:2023-12-27
Method:ELECTRON MICROSCOPY (5.3 Å)
Cite:Cryo-EM structure of influenza helical nucleocapsid reveals NP-NP and NP-RNA interactions as a model for the genome encapsidation.
Sci Adv, 9, 2023
7Q63
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BU of 7q63 by Molmil
The tandem SH2 domains of SYK
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E.
Deposit date:2021-11-05
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The tandem SH2 domains of SYK
To Be Published
7Q5W
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BU of 7q5w by Molmil
The tandem SH2 domains of SYK with a bound TYROBP diphospho-ITAM peptide
Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, ...
Authors:Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E.
Deposit date:2021-11-04
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The tandem SH2 domains of SYK
To Be Published
7Q5T
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BU of 7q5t by Molmil
The tandem SH2 domains of SYK with a bound FCER1G diphospho-ITAM peptide
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, High affinity immunoglobulin epsilon receptor subunit gamma, ...
Authors:Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E.
Deposit date:2021-11-04
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The tandem SH2 domains of SYK
To Be Published
1JE8
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BU of 1je8 by Molmil
Two-Component response regulator NarL/DNA Complex: DNA Bending Found in a High Affinity Site
Descriptor: 5'-D(*CP*GP*TP*AP*CP*CP*CP*AP*TP*TP*AP*AP*TP*GP*GP*GP*TP*AP*CP*G)-3', Nitrate/Nitrite Response Regulator Protein NARL, SULFATE ION
Authors:Maris, A.E, Sawaya, M.R, Kaczor-Grzeskowiak, M, Jarvis, M.R, Bearson, S.M.D, Kopka, M.L, Schroder, I, Gunsalus, R.P, Dickerson, R.E.
Deposit date:2001-06-15
Release date:2002-09-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Dimerization allows DNA target site recognition by the NarL response regulator.
Nat.Struct.Biol., 9, 2002
1FLZ
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BU of 1flz by Molmil
URACIL DNA GLYCOSYLASE WITH UAAP
Descriptor: URACIL, URACIL-DNA GLYCOSYLASE
Authors:Werner, R.M, Jiang, Y.L, Gordley, R.G, Jagadeesh, G.J, Ladner, J.E, Xiao, G, Tordova, M, Gilliland, G.L, Stivers, J.T.
Deposit date:2000-08-15
Release date:2001-01-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Stressing-out DNA? The contribution of serine-phosphodiester interactions in catalysis by uracil DNA glycosylase.
Biochemistry, 39, 2000
7Q5U
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BU of 7q5u by Molmil
The tandem SH2 domains of SYK with a bound CD3G diphospho-ITAM peptide
Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, DI(HYDROXYETHYL)ETHER, ...
Authors:Bradshaw, W.J, Katis, V.L, Chen, Z, Bountra, C, von Delft, F, Gileadi, O, Brennan, P.E.
Deposit date:2021-11-04
Release date:2021-11-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The tandem SH2 domains of SYK
To Be Published

223790

数据于2024-08-14公开中

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