5U2B

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol, without a coactivator peptide

Summary for 5U2B

• Entry DOI: 10.2210/pdb5u2b/pdb
• Related: 5U2D
• Descriptor: Estrogen receptor, (8~{R},9~{S},13~{S},14~{S},17~{S})-13-methyl-17-phenylazanyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-ol (3 entities in total)
• Functional Keywords: protein ligand complex, transcription
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• Total number of polymer chains: 6
• Total formula weight: 177882.17

Authors

Nwachukwu, J.C.,Nowak, J.,Carlson, K.E.,Katzenellenbogen, J.A.,Nettles, K.W. (deposition date: 2016-11-30, release date: 2017-04-26, Last modification date: 2024-03-06)

• Primary citation: Stender, J.D.,Nwachukwu, J.C.,Kastrati, I.,Kim, Y.,Strid, T.,Yakir, M.,Srinivasan, S.,Nowak, J.,Izard, T.,Rangarajan, E.S.,Carlson, K.E.,Katzenellenbogen, J.A.,Yao, X.Q.,Grant, B.J.,Leong, H.S.,Lin, C.Y.,Frasor, J.,Nettles, K.W.,Glass, C.K.; Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.; Mol. Cell, 65:1122-1135.e5, 2017; PubMed: 28306507; DOI: 10.1016/j.molcel.2017.02.008

Experimental method

X-RAY DIFFRACTION (2.22 Å)