7O7Q
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![BU of 7o7q by Molmil](/molmil-images/mine/7o7q) | (h-alpha2M)4 trypsin-activated state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | Authors: | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | Deposit date: | 2021-04-13 | Release date: | 2022-04-13 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7R
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![BU of 7o7r by Molmil](/molmil-images/mine/7o7r) | (h-alpha2M)4 plasmin-activated I state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | Authors: | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | Deposit date: | 2021-04-13 | Release date: | 2022-04-13 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7O7S
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![BU of 7o7s by Molmil](/molmil-images/mine/7o7s) | (h-alpha2M)4 plasmin-activated II state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | Authors: | Luque, D, Goulas, T, Mata, C.P, Mendes, S.R, Gomis-Ruth, F.X, Caston, J.R. | Deposit date: | 2021-04-13 | Release date: | 2022-04-13 | Last modified: | 2022-05-11 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human alpha 2 -macroglobulin. Proc.Natl.Acad.Sci.USA, 119, 2022
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7OP0
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![BU of 7op0 by Molmil](/molmil-images/mine/7op0) | Crystal structure of complement C5 in complex with chemically synthesized K92 knob domain. | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, ... | Authors: | Macpherson, A, van der Elsen, J.M.H, Schulze, M.E, Birtley, J.R. | Deposit date: | 2021-05-28 | Release date: | 2022-04-06 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | The Chemical Synthesis of Knob Domain Antibody Fragments. Acs Chem.Biol., 16, 2021
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7Q1Y
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![BU of 7q1y by Molmil](/molmil-images/mine/7q1y) | X-ray structure of human A2ML1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1, ... | Authors: | Andersen, G.R, Zarantonello, A, Enghild, J.J, Nielsen, N.S. | Deposit date: | 2021-10-22 | Release date: | 2022-04-20 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
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7Q5Z
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![BU of 7q5z by Molmil](/molmil-images/mine/7q5z) | |
7Q60
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![BU of 7q60 by Molmil](/molmil-images/mine/7q60) | |
7Q61
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![BU of 7q61 by Molmil](/molmil-images/mine/7q61) | Structure of TEV conjugated A2ML1 (A2ML1-TC) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin-like protein 1 | Authors: | Nielsen, N.S, Zarantonello, A, Andersen, G.R. | Deposit date: | 2021-11-05 | Release date: | 2022-04-20 | Last modified: | 2022-11-02 | Method: | ELECTRON MICROSCOPY (2.88 Å) | Cite: | Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family. Nat Commun, 13, 2022
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7Q62
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![BU of 7q62 by Molmil](/molmil-images/mine/7q62) | |
7QIV
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![BU of 7qiv by Molmil](/molmil-images/mine/7qiv) | Structure of human C3b in complex with the EWE nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | Authors: | Pedersen, H, Andersen, G.R. | Deposit date: | 2021-12-16 | Release date: | 2022-02-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity. Front Immunol, 13, 2022
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7S62
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![BU of 7s62 by Molmil](/molmil-images/mine/7s62) | |
7S63
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![BU of 7s63 by Molmil](/molmil-images/mine/7s63) | |
7S64
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![BU of 7s64 by Molmil](/molmil-images/mine/7s64) | |
7TV9
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![BU of 7tv9 by Molmil](/molmil-images/mine/7tv9) | HUMAN COMPLEMENT COMPONENT C3B IN COMPLEX WITH APL-1030 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, APL-1030 Nanofitin, Complement C3 beta chain, ... | Authors: | Fontano, E, Nadupalli, A, Lakshminarasimhan, D, White, A, Garlish, J, Cinier, M, Chevrel, A, Perrocheau, A, Eyerman, D, Orme, M, Kitten, O, Scheibler, L. | Deposit date: | 2022-02-04 | Release date: | 2022-03-30 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Discovery of APL-1030, a Novel, High-Affinity Nanofitin Inhibitor of C3-Mediated Complement Activation. Biomolecules, 12, 2022
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7VON
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![BU of 7von by Molmil](/molmil-images/mine/7von) | Native alpha-2-macroglobulin monomer | Descriptor: | Alpha-2-macroglobulin | Authors: | Huang, X, Wang, Y. | Deposit date: | 2021-10-14 | Release date: | 2022-11-16 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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7VOO
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![BU of 7voo by Molmil](/molmil-images/mine/7voo) | Induced alpha-2-macroglobulin monomer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-2-macroglobulin, ... | Authors: | Huang, X, Wang, Y, Ping, Z. | Deposit date: | 2021-10-14 | Release date: | 2022-10-19 | Last modified: | 2022-12-07 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structures reveal the dynamic transformation of human alpha-2-macroglobulin working as a protease inhibitor. Sci China Life Sci, 65, 2022
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7ZGJ
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![BU of 7zgj by Molmil](/molmil-images/mine/7zgj) | |
7ZGK
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![BU of 7zgk by Molmil](/molmil-images/mine/7zgk) | |
8AYH
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![BU of 8ayh by Molmil](/molmil-images/mine/8ayh) | |
8B0F
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![BU of 8b0f by Molmil](/molmil-images/mine/8b0f) | CryoEM structure of C5b8-CD59 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Bubeck, D, Couves, E.C, Gardner, S. | Deposit date: | 2022-09-07 | Release date: | 2023-02-22 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
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8B0G
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![BU of 8b0g by Molmil](/molmil-images/mine/8b0g) | 2C9, C5b9-CD59 structure | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD59 glycoprotein, Complement C5, ... | Authors: | Couves, E.C, Gardner, S, Bubeck, D. | Deposit date: | 2022-09-07 | Release date: | 2023-02-22 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
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8B0H
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![BU of 8b0h by Molmil](/molmil-images/mine/8b0h) | 2C9, C5b9-CD59 cryoEM structure | Descriptor: | CD59 glycoprotein, Complement C5, Complement component C6, ... | Authors: | Couves, E.C, Gardner, S, Bubeck, D. | Deposit date: | 2022-09-07 | Release date: | 2023-02-22 | Last modified: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for membrane attack complex inhibition by CD59. Nat Commun, 14, 2023
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8CEM
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![BU of 8cem by Molmil](/molmil-images/mine/8cem) | Structure of bovine native C3, re-refinement | Descriptor: | Complement C3 alpha chain, Complement C3 beta chain, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Andersen, G.R, Fredslund, F. | Deposit date: | 2023-02-02 | Release date: | 2023-04-05 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The structure of bovine complement component 3 reveals the basis for thioester function. J Mol Biol, 361, 2006
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8CML
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![BU of 8cml by Molmil](/molmil-images/mine/8cml) | |
8COE
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![BU of 8coe by Molmil](/molmil-images/mine/8coe) | complement C5 in complex with the LCP0195 nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C5 alpha chain, Complement C5 beta chain, ... | Authors: | Andersen, G.R, Pedersen, D.V. | Deposit date: | 2023-02-28 | Release date: | 2024-01-03 | Method: | X-RAY DIFFRACTION (4.2 Å) | Cite: | Characterization of the bispecific VHH antibody gefurulimab (ALXN1720) targeting complement component 5, and designed for low volume subcutaneous administration. Mol.Immunol., 165, 2023
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