7QIV

Structure of human C3b in complex with the EWE nanobody

Summary for 7QIV

• Entry DOI: 10.2210/pdb7qiv/pdb
• Related: 6EHG 6RU5
• Descriptor: Complement C3 beta chain, Complement C3b alpha' chain, Nanobody EWE, ... (4 entities in total)
• Functional Keywords: complement, alternative pathway, antibody, nanobody, protein engineering, immune system
• Biological source: Lama glama; More
• Total number of polymer chains: 3
• Total formula weight: 190700.22

Authors

Pedersen, H.,Andersen, G.R. (deposition date: 2021-12-16, release date: 2022-02-16, Last modification date: 2024-01-31)

• Primary citation: Pedersen, H.,Jensen, R.K.,Hansen, A.G.,Petersen, S.V.,Thiel, S.,Laursen, N.S.,Andersen, G.R.; Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.; Front Immunol, 13:872536-872536, 2022; PubMed: 35935935; DOI: 10.3389/fimmu.2022.872536

Experimental method

X-RAY DIFFRACTION (2.8 Å)