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6U8O	Discovery and optimization of salicyclic acid-derived sulfonamide inhibitors of the WDR5:MYC protein-protein interaction Descriptor: 5-bromo-N-[5-(1-cyanocyclobutyl)-2-hydroxyphenyl]-2-hydroxybenzene-1-sulfonamide, WD repeat-containing protein 5 Authors: Zhao, B, Wang, F. Deposit date: 2019-09-05 Release date: 2019-12-04 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction. J.Med.Chem., 62, 2019
6UJ4	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction Descriptor: 5-bromo-3-chloro-N-(1-cyclopentyl-2-methyl-1H-imidazol-4-yl)-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 Authors: Zhao, B. Deposit date: 2019-10-02 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.53 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UJL	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction Descriptor: 6-methyl-3-(propylsulfanyl)-1,2,4-triazin-5-ol, WD repeat-containing protein 5 Authors: Phan, J. Deposit date: 2019-10-03 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.599 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6UJJ	Discovery of fragment-inspired heterocyclic benzenesulfonamides as inhibitors of the WDR5-MYC interaction Descriptor: 5-[4-(trifluoromethyl)phenyl]-1H-tetrazole, WD repeat-containing protein 5 Authors: Phan, J. Deposit date: 2019-10-03 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.731 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
6BEV	Human Single Domain Sulfurtranferase TSTD1 Descriptor: Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 Authors: Motl, N, Akey, D.L, Smith, J.L, Banerjee, R. Deposit date: 2017-10-25 Release date: 2018-01-24 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.043 Å) Cite: Thiosulfate sulfurtransferase-like domain-containing 1 protein interacts with thioredoxin. J. Biol. Chem., 293, 2018
6OSJ	Cryo-EM structure of the N-terminally acetylated full length alpha-synuclein fibrils (Ac1-140) Descriptor: Alpha-synuclein Authors: Xiaodan, N, Ryan, P.M, Jiansen, J, Jennifer, C.L. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
8GI6	Crystal structure of RhoA mutant L69R complexed with GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA Authors: Chen, X, Qian, X, Chandravanshi, M, Lowy, D.R, Walters, K.J. Deposit date: 2023-03-13 Release date: 2024-03-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Ras-like GTPases mutant structures To be published
8GI3	Crystal structure of RhoA mutant L69P complexed with GDP Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA Authors: Chen, X, Qian, X, Chandravanshi, M, Lowy, D.R, Walters, K.J. Deposit date: 2023-03-13 Release date: 2024-03-20 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.52 Å) Cite: Ras-like GTPases mutants structure To be published
6OSL	Cryo-EM structure of the N-terminally acetylated C-terminal Alpha-synuclein truncation Ac1-122 Descriptor: Alpha-synuclein Authors: Ni, X, McGlinchey, R.P, Jiang, J, Lee, J.C. Deposit date: 2019-05-01 Release date: 2019-09-25 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural Insights into alpha-Synuclein Fibril Polymorphism: Effects of Parkinson's Disease-Related C-Terminal Truncations. J.Mol.Biol., 431, 2019
8F1G	Crystal structure of human WDR5 in complex with compound WM662 Descriptor: (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, SULFATE ION, ... Authors: Liu, H. Deposit date: 2022-11-05 Release date: 2023-01-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18, 2023
2GRO	Crystal Structure of human RanGAP1-Ubc9-N85Q Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I Authors: Yunus, A.A, Lima, C.D. Deposit date: 2006-04-24 Release date: 2006-05-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
2GRN	Crystal Structure of human RanGAP1-Ubc9 Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I Authors: Yunus, A.A, Lima, C.D. Deposit date: 2006-04-24 Release date: 2006-05-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
7N1R	A novel and unique ATP hydrolysis to AMP by a human Hsp70 BiP Descriptor: ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP, ... Authors: Yang, J, Musayev, F, Liu, Q. Deposit date: 2021-05-28 Release date: 2022-01-12 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.03 Å) Cite: A novel and unique ATP hydrolysis to AMP by a human Hsp70 Binding immunoglobin protein (BiP). Protein Sci., 31, 2022
4LL1	The structure of the TRX and TXNIP complex Descriptor: Thioredoxin, Thioredoxin-interacting protein Authors: Hwang, J, Kim, M.H. Deposit date: 2013-07-09 Release date: 2014-02-05 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2 Å) Cite: The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein Nat Commun, 5, 2014
6PES	Cryo-EM structure of alpha-synuclein H50Q Wide Fibril Descriptor: Alpha-synuclein Authors: Boyer, D.R, Li, B, Sawaya, M.R, Jiang, L, Eisenberg, D.S. Deposit date: 2019-06-20 Release date: 2019-11-27 Last modified: 2024-03-20 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structures of fibrils formed by alpha-synuclein hereditary disease mutant H50Q reveal new polymorphs. Nat.Struct.Mol.Biol., 26, 2019
2GRQ	Crystal Structure of human RanGAP1-Ubc9-D127A Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I Authors: Yunus, A.A, Lima, C.D. Deposit date: 2006-04-24 Release date: 2006-05-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
4Q0X	Crystal structure of non-neutralizing antibody in complex with Epitope II of HCV E2 Descriptor: Envelope glycoprotein E2, mAb 12 heavy chain, mAb 12 light chain Authors: Deng, L, Zhang, P. Deposit date: 2014-04-02 Release date: 2014-07-09 Last modified: 2014-08-06 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization. Proc.Natl.Acad.Sci.USA, 111, 2014
2GRR	Crystal Structure of human RanGAP1-Ubc9-D127S Descriptor: Ran GTPase-activating protein 1, Ubiquitin-conjugating enzyme E2 I Authors: Yunus, A.A, Lima, C.D. Deposit date: 2006-04-24 Release date: 2006-05-30 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat.Struct.Mol.Biol., 13, 2006
2M4H	Solution structure of the Core Domain (10-76) of the Feline Calicivirus VPg protein Descriptor: Feline Calicivirus VPg protein Authors: Kwok, R.N, Leen, E.N, Birtley, J.R, Prater, S.N, Simpson, P.J, Curry, S, Matthews, S, Marchant, J. Deposit date: 2013-02-05 Release date: 2013-03-27 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Structures of the Compact Helical Core Domains of Feline Calicivirus and Murine Norovirus VPg Proteins. J.Virol., 87, 2013
1L8Y	Solution structure of HMG box 5 in human upstream binding factor Descriptor: upstream binding factor 1 Authors: Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. Deposit date: 2002-03-22 Release date: 2002-06-05 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
8F93	WDR5 covalently modified at Y228 by (R)-2-SF Descriptor: 3-ethynyl-5-{[(3R)-4-{1-[(2-methoxyphenyl)methyl]-1H-benzimidazole-5-carbonyl}-3-methylpiperazin-1-yl]methyl}benzene-1-sulfonyl fluoride, CHLORIDE ION, GLYCEROL, ... Authors: Taunton, J, Craven, G.B, Chen, Y. Deposit date: 2022-11-23 Release date: 2023-05-31 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. Nat.Chem., 15, 2023
1L8Z	Solution structure of HMG box 5 in human upstream binding factor Descriptor: upstream binding factor 1 Authors: Yang, W, Xu, Y, Wu, J, Zeng, W, Shi, Y. Deposit date: 2002-03-22 Release date: 2002-06-05 Last modified: 2024-05-29 Method: SOLUTION NMR Cite: Solution structure and DNA binding property of the fifth HMG box domain in comparison with the first HMG box domain in human upstream binding factor Biochemistry, 42, 2003
6UOZ	Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction Descriptor: 5-bromo-3-chloro-N-[1-cyclopentyl-2-(methylsulfonyl)-1H-imidazol-4-yl]-2-hydroxybenzene-1-sulfonamide, WD repeat domain 5 Authors: Zhao, B. Deposit date: 2019-10-16 Release date: 2020-04-15 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.532 Å) Cite: Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63, 2020
5Y81	NuA4 TEEAA sub-complex Descriptor: Actin, Actin-related protein 4, Chromatin modification-related protein EAF1, ... Authors: Wang, X, Cai, G. Deposit date: 2017-08-18 Release date: 2018-04-18 Last modified: 2019-11-06 Method: ELECTRON MICROSCOPY (4.7 Å) Cite: Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex Nat Commun, 9, 2018
5TUU	Crystal structure of the E2F4-DP1 coiled coil and marked-box domains Descriptor: GLYCEROL, Transcription factor DP1, Transcription factor E2F4 Authors: Liban, T.J, Rubin, S.M, Tripathi, S.M. Deposit date: 2016-11-07 Release date: 2017-05-03 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.251 Å) Cite: Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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