8F1G

Crystal structure of human WDR5 in complex with compound WM662

Summary for 8F1G

• Entry DOI: 10.2210/pdb8f1g/pdb
• Descriptor: WD repeat-containing protein 5, (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, ... (6 entities in total)
• Functional Keywords: wdr5, wm662, myc, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 71295.29

Authors

Liu, H. (deposition date: 2022-11-05, release date: 2023-01-11, Last modification date: 2023-10-25)

• Primary citation: Ding, J.,Li, G.,Liu, H.,Liu, L.,Lin, Y.,Gao, J.,Zhou, G.,Shen, L.,Zhao, M.,Yu, Y.,Guo, W.,Hommel, U.,Ottl, J.,Blank, J.,Aubin, N.,Wei, Y.,He, H.,Sage, D.R.,Atadja, P.W.,Li, E.,Jain, R.K.,Tallarico, J.A.,Canham, S.M.,Chiang, Y.L.,Wang, H.; Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.; Acs Chem.Biol., 18:34-40, 2023; PubMed: 36594833; DOI: 10.1021/acschembio.2c00843

Experimental method

X-RAY DIFFRACTION (2.14 Å)