8F1G
Crystal structure of human WDR5 in complex with compound WM662
Summary for 8F1G
Entry DOI | 10.2210/pdb8f1g/pdb |
Descriptor | WD repeat-containing protein 5, (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid, GLYCEROL, ... (6 entities in total) |
Functional Keywords | wdr5, wm662, myc, oncoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 71295.29 |
Authors | |
Primary citation | Ding, J.,Li, G.,Liu, H.,Liu, L.,Lin, Y.,Gao, J.,Zhou, G.,Shen, L.,Zhao, M.,Yu, Y.,Guo, W.,Hommel, U.,Ottl, J.,Blank, J.,Aubin, N.,Wei, Y.,He, H.,Sage, D.R.,Atadja, P.W.,Li, E.,Jain, R.K.,Tallarico, J.A.,Canham, S.M.,Chiang, Y.L.,Wang, H. Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction. Acs Chem.Biol., 18:34-40, 2023 Cited by PubMed: 36594833DOI: 10.1021/acschembio.2c00843 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.14 Å) |
Structure validation
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