8F1G
Crystal structure of human WDR5 in complex with compound WM662
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | WD repeat-containing protein 5 | polymer | 316 | 34663.3 | 2 | UniProt (P61964) Pfam (PF00400) | Homo sapiens (human) | BMP2-induced 3-kb gene protein |
| 2 | C, J (A, B) | (2S)-2-({(2S)-3-(3'-chloro[1,1'-biphenyl]-4-yl)-1-oxo-1-[(1H-tetrazol-5-yl)amino]propan-2-yl}oxy)propanoic acid | non-polymer | 415.8 | 2 | Chemie (X8N) | |||
| 3 | D, E, F, G, K... (A, B) | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
| 4 | H, N (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | I, O (A, B) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 6 | P, Q (A, B) | water | water | 18.0 | 268 | Chemie (HOH) |
Sequence modifications
A, B: 22 - 334 (UniProt: P61964)
| PDB | External Database | Details |
|---|---|---|
| Ser 19 | - | expression tag |
| Asn 20 | - | expression tag |
| Ala 21 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69326.5 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 1968.8 | |
| All* | Total formula weight | 71295.3 |
