The structure of the TRX and TXNIP complex

Summary for 4LL1

Related4GFX 4LL4
DescriptorThioredoxin-interacting protein, Thioredoxin (3 entities in total)
Functional Keywordsarrestin-like domain, antitumor protein-protein binding complex, antitumor protein/protein binding
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity) Q9H3M7
Nucleus P10599
Total number of polymer chains4
Total molecular weight93479.69
Hwang, J.,Kim, M.H. (deposition date: 2013-07-09, release date: 2014-02-05)
Primary citation
Hwang, J.,Suh, H.W.,Jeon, Y.H.,Hwang, E.,Nguyen, L.T.,Yeom, J.,Lee, S.G.,Lee, C.,Kim, K.J.,Kang, B.S.,Jeong, J.O.,Oh, T.K.,Choi, I.,Lee, J.O.,Kim, M.H.
The structural basis for the negative regulation of thioredoxin by thioredoxin-interacting protein
Nat Commun, 5:2958-2958, 2014
PubMed: 24389582 (PDB entries with the same primary citation)
DOI: 10.1038/ncomms3958
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.28180.5%7.9%7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload