4LL1
The structure of the TRX and TXNIP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0009314 | biological_process | response to radiation |
| B | 0015035 | molecular_function | protein-disulfide reductase activity |
| B | 0019725 | biological_process | cellular homeostasis |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043388 | biological_process | positive regulation of DNA binding |
| B | 0045454 | biological_process | cell redox homeostasis |
| B | 0047134 | molecular_function | protein-disulfide reductase [NAD(P)H] activity |
| B | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| B | 0055114 | biological_process | obsolete oxidation-reduction process |
| B | 0061692 | biological_process | cellular detoxification of hydrogen peroxide |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071731 | biological_process | response to nitric oxide |
| D | 0003723 | molecular_function | RNA binding |
| D | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005576 | cellular_component | extracellular region |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006351 | biological_process | DNA-templated transcription |
| D | 0009314 | biological_process | response to radiation |
| D | 0015035 | molecular_function | protein-disulfide reductase activity |
| D | 0019725 | biological_process | cellular homeostasis |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0043388 | biological_process | positive regulation of DNA binding |
| D | 0045454 | biological_process | cell redox homeostasis |
| D | 0047134 | molecular_function | protein-disulfide reductase [NAD(P)H] activity |
| D | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| D | 0055114 | biological_process | obsolete oxidation-reduction process |
| D | 0061692 | biological_process | cellular detoxification of hydrogen peroxide |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0071731 | biological_process | response to nitric oxide |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"20068034","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 206 |
| Details | Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9108029","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Site: {"description":"Deprotonates C-terminal active site Cys","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Contributes to redox potential value","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"17260951","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine; alternate","evidences":[{"source":"PubMed","id":"16408020","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17606900","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P10639","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
