6UOZ

Discovery of fragment-inspired heterocyclic benzenesulfonmides as inhibitors of the WDR5-MYC interaction

Summary for 6UOZ

Entry DOI	10.2210/pdb6uoz/pdb
Descriptor	WD repeat domain 5, 5-bromo-3-chloro-N-[1-cyclopentyl-2-(methylsulfonyl)-1H-imidazol-4-yl]-2-hydroxybenzene-1-sulfonamide (3 entities in total)
Functional Keywords	wdr5, myc, structure-based design, fragment screening, transcription
Biological source	Homo sapiens
Total number of polymer chains	2
Total formula weight	67981.64
Authors	Zhao, B. (deposition date: 2019-10-16, release date: 2020-04-15, Last modification date: 2023-10-11)
Primary citation	Chacon Simon, S.,Wang, F.,Thomas, L.R.,Phan, J.,Zhao, B.,Olejniczak, E.T.,Macdonald, J.D.,Shaw, J.G.,Schlund, C.,Payne, W.,Creighton, J.,Stauffer, S.R.,Waterson, A.G.,Tansey, W.P.,Fesik, S.W. Discovery of WD Repeat-Containing Protein 5 (WDR5)-MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design. J.Med.Chem., 63:4315-4333, 2020 Cited by PubMed: 32223236 DOI: 10.1021/acs.jmedchem.0c00224 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.532 Å)

Structure validation