PDB: 52994 resultsInfo pagesStatus searchChemie searchBIRD

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3QQC	Crystal structure of archaeal Spt4/5 bound to the RNAP clamp domain Descriptor: DNA-directed RNA polymerase subunit b, DNA-directed RNA polymerase subunit a', DNA-directed RNA polymerase subunit A'', ... Authors: Martinez-Rucobo, F.W. Deposit date: 2011-02-15 Release date: 2011-03-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Architecture of the RNA polymerase-Spt4/5 complex and basis of universal transcription processivity. Embo J., 30, 2011
3ZFD	Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP Descriptor: CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. Deposit date: 2012-12-11 Release date: 2013-03-20 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Structural Basis for the ATP-Induced Isomerization of Kinesin. J.Mol.Biol., 425, 2013
5T31	Exploiting an Asp-Glu switch in Glycogen Synthase Kinase 3 to design paralog selective inhibitors for use in acute myeloid leukemia Descriptor: (4~{S})-4-ethyl-7,7-dimethyl-4-phenyl-2,6,8,9-tetrahydropyrazolo[3,4-b]quinolin-5-one, Glycogen synthase kinase-3 beta Authors: Stein, A.J, Holson, E.B, Wagner, F.F, Cambell, A.J. Deposit date: 2016-08-24 Release date: 2018-02-21 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Exploiting an Asp-Glu "switch" in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia. Sci Transl Med, 10, 2018
4CTI	Escherichia coli EnvZ histidine kinase catalytic part fused to Archaeoglobus fulgidus Af1503 HAMP domain Descriptor: OSMOLARITY SENSOR PROTEIN ENVZ, AF1503 Authors: Ferris, H.U, Coles, M, Lupas, A.N, Hartmann, M.D. Deposit date: 2014-03-13 Release date: 2014-04-09 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.847 Å) Cite: Crystallographic Snapshot of the Escherichia Coli Envz Histidine Kinase in an Active Conformation. J.Struct.Biol., 186, 2014
5TQQ	Cryo-electron microscopy structure of a bovine CLC-K chloride channel, main (class 1) conformation Descriptor: Chloride channel protein, Monoclonal antibody, Fab fragment, ... Authors: Park, E, MacKinnon, R. Deposit date: 2016-10-24 Release date: 2017-01-04 Last modified: 2019-11-20 Method: ELECTRON MICROSCOPY (3.76 Å) Cite: Structure of a CLC chloride ion channel by cryo-electron microscopy. Nature, 541, 2017
3ZFC	Crystal Structure of the Kif4 Motor Domain Complexed With Mg-AMPPNP Descriptor: CHROMOSOME-ASSOCIATED KINESIN KIF4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER Authors: Chang, Q, Nitta, R, Inoue, S, Hirokawa, N. Deposit date: 2012-12-11 Release date: 2013-03-20 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Basis for the ATP-Induced Isomerization of Kinesin. J.Mol.Biol., 425, 2013
5TR1	Cryo-electron microscopy structure of a bovine CLC-K chloride channel, alternate (class 2) conformation Descriptor: CHOLESTEROL HEMISUCCINATE, Chloride channel protein, Monoclonal antibody, ... Authors: Park, E, MacKinnon, R. Deposit date: 2016-10-25 Release date: 2017-01-11 Last modified: 2019-11-20 Method: ELECTRON MICROSCOPY (3.95 Å) Cite: Structure of a CLC chloride ion channel by cryo-electron microscopy. Nature, 541, 2017
8RKG	Crystal structure of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BICINE, ... Authors: Nishio, S, de Sanctis, D, Jovine, L. Deposit date: 2023-12-25 Release date: 2024-03-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Cell, 187, 2024
8RKF	Crystal structure of the ZP-N1 and ZP-N2 domains of human ZP2 (hZP2-N1N2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Zona pellucida sperm-binding protein 2 Authors: Dioguardi, E, Stsiapanava, A, de Sanctis, D, Jovine, L. Deposit date: 2023-12-25 Release date: 2024-03-13 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (3.2 Å) Cite: ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat. Cell, 187, 2024
8GK3	Cytochrome P450 3A7 in complex with Dehydroepiandrosterone sulfate Descriptor: 17-oxoandrost-5-en-3beta-yl hydrogen sulfate, Cytochrome P450 3A7, PROTOPORPHYRIN IX CONTAINING FE Authors: Liu, J, Scott, E.E. Deposit date: 2023-03-16 Release date: 2023-07-26 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Human cytochrome P450 3A7 binding four copies of its native substrate dehydroepiandrosterone 3-sulfate. J.Biol.Chem., 299, 2023
6IO0	Human IDH1 R132C mutant complexed with compound A. Descriptor: (2E)-3-{3-[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazole-4-carbonyl]-1-methyl-1H-indol-7-yl}prop-2-enoic acid, CITRIC ACID, GLYCEROL, ... Authors: Suzuki, M, Baba, D, Hanzawa, H. Deposit date: 2018-10-29 Release date: 2019-10-30 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A Potent Blood-Brain Barrier-Permeable Mutant IDH1 Inhibitor Suppresses the Growth of Glioblastoma with IDH1 Mutation in a Patient-Derived Orthotopic Xenograft Model. Mol.Cancer Ther., 19, 2020
6J9J	crystal structure of SESTD2 in complex with H3.3S31phK36M peptide Descriptor: H3.3S31phK36M(29-42), Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... Authors: Yang, S, Li, H.T. Deposit date: 2019-01-23 Release date: 2020-02-26 Last modified: 2020-08-12 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Histone H3.3 phosphorylation amplifies stimulation-induced transcription. Nature, 583, 2020
5OKP	Crystal structure of human SHIP2 Phosphatase-C2 double mutant F593D/L597D Descriptor: 1,2-ETHANEDIOL, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Authors: Le Coq, J, Lietha, D. Deposit date: 2017-07-25 Release date: 2017-08-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife, 6, 2017
5OKM	Crystal structure of human SHIP2 Phosphatase-C2 Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, NITRATE ION, ... Authors: Le Coq, J, Lietha, D. Deposit date: 2017-07-25 Release date: 2017-08-23 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.96 Å) Cite: Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife, 6, 2017
8SZ3	Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 7j Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(1S)-1-(5-bromopyridin-2-yl)ethyl]-3-[(2R)-3,3-dimethylbutan-2-yl]-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxamide, ... Authors: Sudom, A, Min, X. Deposit date: 2023-05-26 Release date: 2023-12-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors. J.Med.Chem., 66, 2023
5OKN	Crystal structure of human SHIP2 Phosphatase-C2 D607A mutant Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, ... Authors: Le Coq, J, Lietha, D. Deposit date: 2017-07-25 Release date: 2017-08-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife, 6, 2017
5OKO	Crystal structure of human SHIP2 Phosphatase-C2 double mutant F593D/L597D Descriptor: 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Authors: Le Coq, J, Lietha, D. Deposit date: 2017-07-25 Release date: 2017-08-23 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Structural basis for interdomain communication in SHIP2 providing high phosphatase activity. Elife, 6, 2017
7L5A	Crystal structure of the photosensory module from Xanthomonas campestris bacteriophytochrome XccBphP in the Pfr state Descriptor: BILIVERDINE IX ALPHA, Bacteriophytochrome Authors: Otero, L.H, Antelo, G, Sanchez-Lamas, M, Klinke, S, Goldbaum, F.A, Rinaldi, J, Bonomi, H.R. Deposit date: 2020-12-21 Release date: 2021-12-29 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.95 Å) Cite: Structural basis for the Pr-Pfr long-range signaling mechanism of a full-length bacterial phytochrome at the atomic level. Sci Adv, 7, 2021
7L59	Crystal structure of the dark-adapted full-length bacteriophytochrome XccBphP-G454E variant from Xanthomonas campestris in the Pfr state Descriptor: BILIVERDINE IX ALPHA, Bacteriophytochrome Authors: Otero, L.H, Antelo, G, Sanchez-Lamas, M, Klinke, S, Goldbaum, F.A, Rinaldi, J, Bonomi, H.R. Deposit date: 2020-12-21 Release date: 2021-12-29 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.68 Å) Cite: Structural basis for the Pr-Pfr long-range signaling mechanism of a full-length bacterial phytochrome at the atomic level. Sci Adv, 7, 2021
8TIC	Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-methylpropyl)-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxylic acid, CHLORIDE ION, ... Authors: Sudom, A, Min, X. Deposit date: 2023-07-19 Release date: 2023-12-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors. J.Med.Chem., 66, 2023
8TJC	Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 8a Descriptor: (6M)-1-[(2R)-3,3-dimethylbutan-2-yl]-6-[(5S)-5-methyl-4-oxo-5-phenyl-4,5-dihydro-1H-imidazol-2-yl]-1,3-dihydro-2H-benzimidazol-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Sudom, A, Min, X. Deposit date: 2023-07-20 Release date: 2023-12-06 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors. J.Med.Chem., 66, 2023
6HY8	Cu(II)-substituted Wells-Dawson binding to Hen Egg-White Lysozyme (HEWL) Descriptor: CHLORIDE ION, Cu(II)-substituted Wells-Dawson, Lysozyme C, ... Authors: Vandebroek, L, Van Meervelt, L, Parac-Vogt, T.N. Deposit date: 2018-10-19 Release date: 2019-10-30 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.22 Å) Cite: Noncovalent Complexes Formed between Metal-Substituted Polyoxometalates and Hen Egg White Lysozyme Eur J Inorg Chem, 2019
8GT4	Crystal structure of human cardiac alpha actin Q137A mutant (AMPPNP state) in complex with fragmin F1 domain Descriptor: 1,2-ETHANEDIOL, Actin, alpha cardiac muscle 1, ... Authors: Iwasa, M, Oda, T, Takeda, S. Deposit date: 2022-09-07 Release date: 2023-03-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis. Front Cell Dev Biol, 11, 2023
8GSW	Crystal structure of human cardiac alpha actin A108G mutant (AMPPNP state) in complex with fragmin F1 domain Descriptor: 1,2-ETHANEDIOL, Actin, alpha cardiac muscle 1, ... Authors: Iwasa, M, Oda, T, Takeda, S. Deposit date: 2022-09-07 Release date: 2023-03-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis. Front Cell Dev Biol, 11, 2023
8GT2	Crystal structure of human cardiac alpha actin P109A mutant (AMPPNP state) in complex with fragmin F1 domain Descriptor: 1,2-ETHANEDIOL, Actin, alpha cardiac muscle 1, ... Authors: Iwasa, M, Oda, T, Takeda, S. Deposit date: 2022-09-07 Release date: 2023-03-08 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Mutagenic analysis of actin reveals the mechanism of His161 flipping that triggers ATP hydrolysis. Front Cell Dev Biol, 11, 2023

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