5OKN

Crystal structure of human SHIP2 Phosphatase-C2 D607A mutant

Summary for 5OKN

• Entry DOI: 10.2210/pdb5okn/pdb
• Descriptor: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: ship2, phosphatase, c2, phosphatidylinositol (3, 4, 5)-triphosphate, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, cytosol: O15357
• Total number of polymer chains: 8
• Total formula weight: 425399.09

Authors

Le Coq, J.,Lietha, D. (deposition date: 2017-07-25, release date: 2017-08-23)

• Primary citation: Le Coq, J.,Camacho-Artacho, M.,Velazquez, J.V.,Santiveri, C.M.,Gallego, L.H.,Campos-Olivas, R.,Dolker, N.,Lietha, D.; Structural basis for interdomain communication in SHIP2 providing high phosphatase activity.; Elife, 6:-, 2017; PubMed: 28792888; DOI: 10.7554/eLife.26640

Experimental method

X-RAY DIFFRACTION (2.65 Å)