5OKN
Crystal structure of human SHIP2 Phosphatase-C2 D607A mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016791 | molecular_function | phosphatase activity |
| A | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| C | 0016791 | molecular_function | phosphatase activity |
| C | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| D | 0016791 | molecular_function | phosphatase activity |
| D | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| E | 0016791 | molecular_function | phosphatase activity |
| E | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| F | 0016791 | molecular_function | phosphatase activity |
| F | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| G | 0016791 | molecular_function | phosphatase activity |
| G | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
| H | 0016791 | molecular_function | phosphatase activity |
| H | 0046856 | biological_process | phosphatidylinositol dephosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue B3P A 901 |
| Chain | Residue |
| A | GLY450 |
| A | LEU451 |
| A | THR454 |
| A | ASP456 |
| A | GLU457 |
| A | ASP711 |
| A | HOH1004 |
| D | GLU642 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 902 |
| Chain | Residue |
| A | SER624 |
| A | HOH1005 |
| A | ILE623 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue B3P B 901 |
| Chain | Residue |
| B | GLY450 |
| B | GLY452 |
| B | THR454 |
| B | ASP456 |
| B | GLU457 |
| B | ASP711 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 902 |
| Chain | Residue |
| B | THR532 |
| B | ILE534 |
| B | GLN574 |
| B | ASN575 |
| B | ASP578 |
| B | HOH1034 |
| H | SER788 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 903 |
| Chain | Residue |
| B | THR759 |
| B | ALA760 |
| B | SER761 |
| B | ARG762 |
| B | ASN790 |
| B | ILE791 |
| B | PHE793 |
| B | LEU794 |
| H | GLN574 |
| H | ASP578 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 904 |
| Chain | Residue |
| B | LEU455 |
| B | THR461 |
| B | ILE462 |
| B | HIS464 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 905 |
| Chain | Residue |
| B | GLN574 |
| B | ASP578 |
| H | THR759 |
| H | ALA760 |
| H | SER788 |
| H | ASN790 |
| H | ILE791 |
| H | PHE793 |
| H | LEU794 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 906 |
| Chain | Residue |
| B | ALA755 |
| B | LYS795 |
| B | GLN797 |
| E | GLN617 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 C 901 |
| Chain | Residue |
| C | ASN432 |
| C | HIS561 |
| C | ASN609 |
| C | HIS718 |
| C | MG902 |
| C | HOH1001 |
| C | HOH1005 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue MG C 902 |
| Chain | Residue |
| C | PO4901 |
| C | HOH1005 |
| site_id | AD2 |
| Number of Residues | 8 |
| Details | binding site for residue B3P C 903 |
| Chain | Residue |
| C | GLY450 |
| C | LEU451 |
| C | GLY452 |
| C | LYS453 |
| C | THR454 |
| C | ASP456 |
| C | GLU457 |
| C | ASP711 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 D 901 |
| Chain | Residue |
| D | ASN432 |
| D | GLU473 |
| D | HIS561 |
| D | SER564 |
| D | ASN609 |
| D | TYR661 |
| D | HIS718 |
| D | MG902 |
| D | HOH1002 |
| D | HOH1021 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 902 |
| Chain | Residue |
| D | GLU473 |
| D | PO4901 |
| D | HOH1002 |
| D | HOH1021 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue B3P D 903 |
| Chain | Residue |
| D | GLY450 |
| D | GLY452 |
| D | THR454 |
| D | ASP456 |
| D | GLU457 |
| D | ASP711 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue EDO D 904 |
| Chain | Residue |
| D | THR759 |
| D | ALA760 |
| D | SER761 |
| D | ARG762 |
| D | ASN790 |
| D | ILE791 |
| D | PHE793 |
| D | LEU794 |
| F | GLN574 |
| F | ASP578 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 905 |
| Chain | Residue |
| D | SER547 |
| D | GLY586 |
| D | ASP587 |
| D | HIS524 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 906 |
| Chain | Residue |
| D | THR532 |
| D | GLY533 |
| D | GLN574 |
| D | ASN575 |
| D | ASP578 |
| F | SER788 |
| site_id | AD9 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 E 901 |
| Chain | Residue |
| E | ASN432 |
| E | GLU473 |
| E | HIS561 |
| E | SER564 |
| E | ASN609 |
| E | TYR661 |
| E | HIS718 |
| E | MG902 |
| E | HOH1004 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 902 |
| Chain | Residue |
| E | ASN432 |
| E | GLU473 |
| E | PO4901 |
| E | HOH1028 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue B3P E 903 |
| Chain | Residue |
| E | GLY450 |
| E | GLY452 |
| E | THR454 |
| E | ASP456 |
| E | GLU457 |
| E | ASP711 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 904 |
| Chain | Residue |
| E | PRO438 |
| E | VAL442 |
| E | TRP481 |
| E | LEU484 |
| E | HOH1002 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 905 |
| Chain | Residue |
| E | LEU455 |
| E | VAL458 |
| E | ILE462 |
| E | HIS464 |
| E | HOH1001 |
| site_id | AE5 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 F 901 |
| Chain | Residue |
| F | ASN432 |
| F | GLU473 |
| F | HIS561 |
| F | SER564 |
| F | ASN609 |
| F | TYR661 |
| F | HIS718 |
| F | MG902 |
| F | HOH1021 |
| F | HOH1023 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue MG F 902 |
| Chain | Residue |
| F | GLU473 |
| F | PO4901 |
| F | HOH1021 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for residue B3P F 903 |
| Chain | Residue |
| F | GLY450 |
| F | GLY452 |
| F | THR454 |
| F | ASP456 |
| F | GLU457 |
| F | ASP711 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO F 904 |
| Chain | Residue |
| F | HIS524 |
| F | SER547 |
| F | PHE548 |
| F | GLY586 |
| F | ASP587 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO F 905 |
| Chain | Residue |
| F | ALA592 |
| F | ASP594 |
| F | GLU836 |
| F | HIS858 |
| F | ARG859 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO F 906 |
| Chain | Residue |
| F | LEU455 |
| F | VAL458 |
| F | ILE462 |
| F | HIS464 |
| site_id | AF2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO F 907 |
| Chain | Residue |
| D | GLN574 |
| F | THR759 |
| F | ALA760 |
| F | SER788 |
| F | ASN790 |
| F | ILE791 |
| F | PHE793 |
| F | LEU794 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 G 901 |
| Chain | Residue |
| G | HIS561 |
| G | SER564 |
| G | ASN609 |
| G | HIS718 |
| G | MG902 |
| G | HOH1001 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue MG G 902 |
| Chain | Residue |
| G | PO4901 |
| G | HOH1007 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO G 903 |
| Chain | Residue |
| G | TYR622 |
| G | GLU627 |
| H | ASN792 |
| H | PHE793 |
| site_id | AF6 |
| Number of Residues | 9 |
| Details | binding site for residue PO4 H 901 |
| Chain | Residue |
| H | ASN432 |
| H | GLU473 |
| H | HIS561 |
| H | SER564 |
| H | ASN609 |
| H | TYR661 |
| H | HIS718 |
| H | MG902 |
| H | HOH1024 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue MG H 902 |
| Chain | Residue |
| H | GLU473 |
| H | PO4901 |
| H | HOH1006 |
| H | HOH1024 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue B3P H 903 |
| Chain | Residue |
| H | GLY450 |
| H | GLY452 |
| H | THR454 |
| H | ASP456 |
| H | GLU457 |
| H | ASP711 |
| H | HOH1003 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 904 |
| Chain | Residue |
| H | SER771 |
| H | THR772 |
| H | HIS820 |
