5OKN
Crystal structure of human SHIP2 Phosphatase-C2 D607A mutant
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 | polymer | 461 | 52706.5 | 8 | UniProt (O15357) | Homo sapiens (Human) | Inositol polyphosphate phosphatase-like protein 1,INPPL-1,Protein 51C,SH2 domain-containing inositol 5'-phosphatase 2,SHIP-2 |
| 2 | BA, GA, I, K, QA... (E, F, A, B, H...) | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 282.3 | 7 | Chemie (B3P) | |||
| 3 | CA, DA, HA, IA, J... (E, F, A, B, G...) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 4 | EA, LA, OA, Q, T... (F, G, H, C, D...) | PHOSPHATE ION | non-polymer | 95.0 | 6 | Chemie (PO4) | |||
| 5 | AA, FA, MA, PA, R... (E, F, G, H, C...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 6 | SA, TA, UA, VA, WA... (A, B, C, D, E...) | water | water | 18.0 | 284 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 420 - 878 (UniProt: O15357)
| PDB | External Database | Details |
|---|---|---|
| Gly 418 | - | expression tag |
| Pro 419 | - | expression tag |
| Ala 607 | Asp 607 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 421651.9 | |
| Non-Polymers* | Number of molecules | 36 |
| Total formula weight | 3747.1 | |
| All* | Total formula weight | 425399.1 |
