8TIC

Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 1

Summary for 8TIC

• Entry DOI: 10.2210/pdb8tic/pdb
• Related: 8SZ3
• Descriptor: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: acetylglucosaminyltransferase, inhibitor, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 189805.59

Authors

Sudom, A.,Min, X. (deposition date: 2023-07-19, release date: 2023-12-06, Last modification date: 2023-12-27)

• Primary citation: Jackson, J.J.,Siegmund, A.C.,Bai, W.J.,Reed, A.B.,Birkholz, A.B.,Campuzano, I.D.G.,Crequer-Grandhomme, A.,Hu, R.,Modak, R.V.,Sudom, A.,Javier, N.,Sanders, C.,Lo, M.C.,Xie, F.,Cee, V.J.,Manzanillo, P.,Allen, J.G.; Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors.; J.Med.Chem., 66:16120-16140, 2023; PubMed: 37988652; DOI: 10.1021/acs.jmedchem.3c01517

Experimental method

X-RAY DIFFRACTION (2.7 Å)