8RKG

Crystal structure of tetrameric collagenase-cleaved Xenopus ZP2-N2N3 (cleaved xZP2-N2N3)

This is a non-PDB format compatible entry.

Summary for 8RKG

• Entry DOI: 10.2210/pdb8rkg/pdb
• Related: 5BUP 5II6 8RKE 8RKF 8RKH
• EMDB information: 19276 19277
• Descriptor: XlZPA protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: cell adhesion, fertilization, egg-sperm interaction, gamete recognition, sperm receptor, extracellular matrix, egg coat, zona pellucida, glycoprotein, n-glycan, structural protein, zp-n domain, block to polyspermy, post-fertilization cleavage, ovastacin, alphafold
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 16
• Total formula weight: 198054.21

Authors

Nishio, S.,de Sanctis, D.,Jovine, L. (deposition date: 2023-12-25, release date: 2024-03-13, Last modification date: 2024-03-27)

• Primary citation: Nishio, S.,Emori, C.,Wiseman, B.,Fahrenkamp, D.,Dioguardi, E.,Zamora-Caballero, S.,Bokhove, M.,Han, L.,Stsiapanava, A.,Algarra, B.,Lu, Y.,Kodani, M.,Bainbridge, R.E.,Komondor, K.M.,Carlson, A.E.,Landreh, M.,de Sanctis, D.,Yasumasu, S.,Ikawa, M.,Jovine, L.; ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat.; Cell, 187:1440-1459.e24, 2024; PubMed: 38490181; DOI: 10.1016/j.cell.2024.02.013

Experimental method

X-RAY DIFFRACTION (2.9 Å)