8TJC
Structure of human beta 1,3-N-acetylglucosaminyltransferase 2 with compound 8a
Summary for 8TJC
Entry DOI | 10.2210/pdb8tjc/pdb |
Related | 8SZ3 8TIC |
Descriptor | N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2, DI(HYDROXYETHYL)ETHER, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total) |
Functional Keywords | acetylglucosaminyltransferase, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 190305.16 |
Authors | |
Primary citation | Jackson, J.J.,Siegmund, A.C.,Bai, W.J.,Reed, A.B.,Birkholz, A.B.,Campuzano, I.D.G.,Crequer-Grandhomme, A.,Hu, R.,Modak, R.V.,Sudom, A.,Javier, N.,Sanders, C.,Lo, M.C.,Xie, F.,Cee, V.J.,Manzanillo, P.,Allen, J.G. Imidazolone as an Amide Bioisostere in the Development of beta-1,3- N -Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors. J.Med.Chem., 66:16120-16140, 2023 Cited by PubMed: 37988652DOI: 10.1021/acs.jmedchem.3c01517 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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