PDB: 46984 resultsInfo pagesStatus searchChemie searchBIRD

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3SM4	Crystal Structure of the K131A Mutant of Lambda Exonuclease in Complex with a 5'-Phosphorylated 14-mer/12-mer Duplex and Magnesium Descriptor: 5'-D(*TP*CP*GP*GP*TP*AP*CP*AP*GP*TP*AP*G)-3', 5'-D(P*AP*GP*CP*TP*AP*CP*TP*GP*TP*AP*CP*CP*GP*A)-3', CHLORIDE ION, ... Authors: Bell, C.E, Zhang, J. Deposit date: 2011-06-27 Release date: 2011-07-20 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Crystal structures of {lambda} exonuclease in complex with DNA suggest an electrostatic ratchet mechanism for processivity. Proc.Natl.Acad.Sci.USA, 108, 2011
3A25	Crystal structure of P. horikoshii TYW2 in complex with AdoMet Descriptor: S-ADENOSYLMETHIONINE, Uncharacterized protein PH0793 Authors: Umitsu, M, Nishimasu, H, Ishitani, R, Nureki, O. Deposit date: 2009-04-28 Release date: 2009-09-15 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2 Proc.Natl.Acad.Sci.USA, 106, 2009
4N8D	DPP4 complexed with syn-7aa Descriptor: 1-(cis-1-phenyl-4-{[(2E)-3-phenylprop-2-en-1-yl]oxy}cyclohexyl)methanamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, Dipeptidyl peptidase 4, ... Authors: Ostermann, N, Zink, F, Kroemer, M. Deposit date: 2013-10-17 Release date: 2014-02-12 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. Bioorg.Med.Chem.Lett., 24, 2014
4NES	Crystal structure of Methanocaldococcus jannaschii UDP-GlcNAc 2-epimerase in complex with UDP-GlcNAc and UDP Descriptor: UDP-N-acetylglucosamine 2-epimerase, URIDINE-5'-DIPHOSPHATE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE Authors: Chen, S.C, Yang, C.S, Huang, C.H, Chen, Y. Deposit date: 2013-10-30 Release date: 2014-04-23 Last modified: 2015-06-17 Method: X-RAY DIFFRACTION (1.42 Å) Cite: Crystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAc. Proteins, 82, 2014
6HP8	Crystal structure of DPP8 in complex with Val-BoroPro Descriptor: Dipeptidyl peptidase 8, GLYCEROL, SODIUM ION, ... Authors: Ross, B.H, Huber, R. Deposit date: 2018-09-19 Release date: 2019-07-31 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Improvement of Protein Crystal Diffraction Using Post-Crystallization Methods: Infrared Laser Radiation Controls Crystal Order Thesis, 2019
2XKC	Structure of Nek2 bound to aminopyrazine compound 14 Descriptor: 4-[3-amino-6-(3,4,5-trimethoxyphenyl)pyrazin-2-yl]-2-methylbenzoic acid, CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK2 Authors: Mas-Droux, C, Bayliss, R. Deposit date: 2010-07-07 Release date: 2010-10-27 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Aminopyrazine Inhibitors Binding to an Unusual Inactive Conformation of the Mitotic Kinase Nek2: Sar and Structural Characterization. J.Med.Chem., 53, 2010
3MGU	Structure of S. cerevisiae Tpa1 protein, a proline hydroxylase modifying ribosomal protein Rps23 Descriptor: FE (II) ION, PKHD-type hydroxylase TPA1 Authors: Henri, J, Rispal, D, Bayart, E, van Tilbeurgh, H, Seraphin, B, Graille, M. Deposit date: 2010-04-07 Release date: 2010-07-14 Last modified: 2018-01-03 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and functional insights into S. cerevisiae Tpa1, a putative prolyl hydroxylase influencing translation termination and transcription To be Published
8GJX	Structure of the human STING receptor bound to 2'3'-cUA Descriptor: 2'3'-cUA, Stimulator of interferon genes protein Authors: Morehouse, B.R, Li, Y, Slavik, K.M, Toyoda, H, Kranzusch, P.J. Deposit date: 2023-03-16 Release date: 2023-07-05 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.6 Å) Cite: cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
2XSH	CRYSTAL STRUCTURE OF P4 VARIANT OF BIPHENYL DIOXYGENASE FROM BURKHOLDERIA XENOVORANS LB400 IN COMPLEX WITH 2,6 DI CHLOROBIPHENYL Descriptor: 2,6-DICHLOROBIPHENYL, BIPHENYL DIOXYGENASE SUBUNIT ALPHA, BIPHENYL DIOXYGENASE SUBUNIT BETA, ... Authors: Kumar, P, Bolin, J.T. Deposit date: 2010-09-29 Release date: 2010-11-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Structural Insight Into the Expanded Pcb-Degrading Abilities of a Biphenyl Dioxygenase Obtained by Directed Evolution. J.Mol.Biol., 405, 2011
8FBB	LH2-LH3 antenna in parallel configuration embedded in a nanodisc Descriptor: BACTERIOCHLOROPHYLL A, LYCOPENE, Light-harvesting protein B-800/850 alpha chain, ... Authors: Toporik, H, Harris, D, Schlau-Cohen, G.S, Mazor, Y. Deposit date: 2022-11-29 Release date: 2023-07-19 Last modified: 2024-06-19 Method: ELECTRON MICROSCOPY (11.3 Å) Cite: Elucidating interprotein energy transfer dynamics within the antenna network from purple bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
1NSI	HUMAN INDUCIBLE NITRIC OXIDE SYNTHASE, ZN-BOUND, L-ARG COMPLEX Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, ARGININE, GLYCEROL, ... Authors: Li, H, Raman, C.S, Glaser, C.B, Blasko, E, Young, T.A, Parkinson, J.F, Whitlow, M, Poulos, T.L. Deposit date: 1999-01-10 Release date: 2000-01-07 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase. J.Biol.Chem., 274, 1999
4YXW	Bovine heart mitochondrial F1-ATPase inhibited by AMP-PNP and ADP in the presence of thiophosphate. Descriptor: ATP synthase subunit alpha, mitochondrial, ATP synthase subunit beta, ... Authors: Bason, J.V, Montgomery, M.G, Leslie, A.G.W, Walker, J.E. Deposit date: 2015-03-23 Release date: 2015-05-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (3.1 Å) Cite: How release of phosphate from mammalian F1-ATPase generates a rotary substep. Proc.Natl.Acad.Sci.USA, 112, 2015
3K2O	Structure of an oxygenase Descriptor: ACETATE ION, Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, CHLORIDE ION, ... Authors: Krojer, T, McDonough, M.A, Clifton, I.J, Mantri, M, Ng, S.S, Pike, A.C.W, Butler, D.S, Webby, C.J, Kochan, G, Bhatia, C, Bray, J.E, Chaikuad, A, Gileadi, O, von Delft, F, Weigelt, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Schofield, C.J, Kavanagh, K.L, Oppermann, U, Structural Genomics Consortium (SGC) Deposit date: 2009-09-30 Release date: 2009-11-03 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal Structure of the 2-Oxoglutarate- and Fe(II)-Dependent Lysyl Hydroxylase JMJD6. J.Mol.Biol., 401, 2010
8GJZ	Structure of a STING receptor from S. pistillata Sp-STING1 bound to 2'3'-cUA Descriptor: 2'3'-cUA, Stimulator of interferon genes protein Authors: Li, Y, Toyoda, H, Slavik, K.M, Morehouse, B.R, Kranzusch, P.J. Deposit date: 2023-03-16 Release date: 2023-07-05 Last modified: 2023-08-02 Method: X-RAY DIFFRACTION (2.92 Å) Cite: cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
4NH5	Structure of human Dicer Platform-PAZ-Connector Helix cassette in complex with 14-mer siRNA having 5'-pUU and UU-3' ends (2.55 Angstrom resolution) Descriptor: 5'-R(P*UP*UP*GP*CP*GP*AP*AP*UP*UP*CP*GP*CP*UP*U)-3', Endoribonuclease Dicer Authors: Tian, Y, Simanshu, D.K, Patel, D.J. Deposit date: 2013-11-04 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.55 Å) Cite: A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer. Mol.Cell, 53, 2014
8GU7	Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs Descriptor: Beclin 1-associated autophagy-related key regulator, Beclin-2 Authors: Qiu, X, Zhao, Y. Deposit date: 2022-09-11 Release date: 2023-07-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs. Autophagy, 19, 2023
2XSO	CRYSTAL STRUCTURE OF P4 VARIANT OF BIPHENYL DIOXYGENASE FROM BURKHOLDERIA XENOVORANS LB400 Descriptor: BIPHENYL DIOXYGENASE SUBUNIT ALPHA, BIPHENYL DIOXYGENASE SUBUNIT BETA, FE (II) ION, ... Authors: Kumar, P, Bolin, J.T. Deposit date: 2010-09-29 Release date: 2010-11-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structural Insight Into the Expanded Pcb-Degrading Abilities of a Biphenyl Dioxygenase Obtained by Directed Evolution. J.Mol.Biol., 405, 2011
6OOE	CTX-M-27 Beta Lactamase with Compound 20 Descriptor: 3-(1H-tetrazol-5-yl)-N-[3-(1H-tetrazol-5-yl)phenyl]-5-(trifluoromethyl)benzamide, Beta-lactamase Authors: Kemp, M, Chen, Y. Deposit date: 2019-04-23 Release date: 2020-07-01 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.26 Å) Cite: An Empirical Study of Amide-Heteroarene pi-Stacking Interactions Using Reversible Inhibitors of a Bacterial Serine Hydrolase. Org Chem Front, 6, 2019
6H0Z	Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR067 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Lysine-specific demethylase 4D, ... Authors: Malecki, P.H, Weiss, M.S, Heinemann, U, Link, A. Deposit date: 2018-07-10 Release date: 2020-01-29 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.34 Å) Cite: Crystal Structure of KDM4D with tetrazolylhydrazide ligand NR067 To be published
8GO3	Cryo-EM structure of Escherichia coli cytochrome bo3 in DDM detergent Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... Authors: Cao, H.Y, Li, K, Li, C.Y. Deposit date: 2022-08-24 Release date: 2023-08-30 Method: ELECTRON MICROSCOPY (3.09 Å) Cite: Cryo-EM structure of Escherichia coli cytochrome bo3 in DDM detergent To Be Published
3A5D	Inter-subunit interaction and quaternary rearrangement defined by the central stalk of prokaryotic V1-ATPase Descriptor: V-type ATP synthase alpha chain, V-type ATP synthase beta chain, V-type ATP synthase subunit D, ... Authors: Numoto, N, Hasegawa, Y, Takeda, K, Miki, K. Deposit date: 2009-08-06 Release date: 2009-10-13 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (4.8 Å) Cite: Inter-subunit interaction and quaternary rearrangement defined by the central stalk of prokaryotic V1-ATPase Embo Rep., 10, 2009
3K3J	P38alpha bound to novel DFG-out compound PF-00416121 Descriptor: 2-(4-fluorophenyl)-3-oxo-6-pyridin-4-yl-N-[2-(trifluoromethyl)benzyl]-2,3-dihydropyridazine-4-carboxamide, 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine, Mitogen-activated protein kinase 14 Authors: Kazmirski, S.L, DiNitto, J.P. Deposit date: 2009-10-02 Release date: 2009-11-10 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.995 Å) Cite: The Design, Synthesis and Potential Utility of Fluorescence Probes that Target DFG-out Conformation of p38alpha for High Throughput Screening Binding Assay. Chem.Biol.Drug Des., 74, 2009
8G9B	Human IMPDH2 mutant - L245P, treated with GTP, ATP, IMP, and NAD+; compressed filament segment reconstruction Descriptor: ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, ... Authors: O'Neill, A.G, Kollman, J.M. Deposit date: 2023-02-21 Release date: 2023-04-19 Last modified: 2023-08-09 Method: ELECTRON MICROSCOPY (3 Å) Cite: Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
8G8F	Human IMPDH2 mutant - L245P, treated with ATP, IMP, and NAD+; extended filament segment reconstruction Descriptor: ADENOSINE-5'-TRIPHOSPHATE, INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase 2, ... Authors: O'Neill, A.G, Kollman, J.M. Deposit date: 2023-02-17 Release date: 2023-04-19 Last modified: 2023-08-09 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Neurodevelopmental disorder mutations in the purine biosynthetic enzyme IMPDH2 disrupt its allosteric regulation. J.Biol.Chem., 299, 2023
4OJN	Crystal structure of human muscle L-lactate dehydrogenase Descriptor: GLYCEROL, L-lactate dehydrogenase A chain, PENTAETHYLENE GLYCOL Authors: Kolappan, S, Craig, L. Deposit date: 2014-01-21 Release date: 2014-12-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015

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