8GU7

Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs

Summary for 8GU7

• Entry DOI: 10.2210/pdb8gu7/pdb
• Descriptor: Beclin 1-associated autophagy-related key regulator, Beclin-2 (3 entities in total)
• Functional Keywords: pi3kc3 complex, beclin 2, autophagy, structural protein
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 4
• Total formula weight: 35984.28

Authors

Qiu, X.,Zhao, Y. (deposition date: 2022-09-11, release date: 2023-07-26, Last modification date: 2023-10-11)

• Primary citation: Qiu, X.,Li, N.,Yang, Q.,Wu, S.,Li, X.,Pan, X.,Yamamoto, S.,Zhang, X.,Zeng, J.,Liao, J.,He, C.,Wang, R.,Zhao, Y.; The potent BECN2-ATG14 coiled-coil interaction is selectively critical for endolysosomal degradation of GPRASP1/GASP1-associated GPCRs.; Autophagy, 19:2884-2898, 2023; PubMed: 37409929; DOI: 10.1080/15548627.2023.2233872

Experimental method

X-RAY DIFFRACTION (2.6 Å)