8GU7
Selective targeting of the Beclin 2-Atg14L coiled coil complex by stapled peptides promotes autophagy and endolysosomal trafficking of GPCRs
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Beclin 1-associated autophagy-related key regulator | polymer | 60 | 7021.2 | 2 | UniProt (Q8CDJ3) In PDB | Mus musculus (house mouse) | Barkor,Autophagy-related protein 14-like protein,Atg14L |
2 | C, D | Beclin-2 | polymer | 96 | 10970.9 | 2 | UniProt (A8MW95) Pfam (PF17675) In PDB | Homo sapiens (human) | Beclin-1 autophagy-related pseudogene 1,Beclin-1-like protein 1 |
3 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 5 - 58 (UniProt: Q8CDJ3)
C, D: 5 - 96 (UniProt: A8MW95)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Pro 0 | - | expression tag |
Gly 1 | - | expression tag |
Ser 2 | - | expression tag |
Gly 3 | - | expression tag |
Ser 4 | - | expression tag |
Leu 20 | Cys 116 | engineered mutation |
Ser 32 | Cys 128 | engineered mutation |
Leu 34 | Gly 130 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 1 | - | expression tag |
Pro 2 | - | expression tag |
Gly 3 | - | expression tag |
Ser 4 | - | expression tag |
Leu 91 | Arg 243 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 35984.3 | |
All* | Total formula weight | 35984.3 |