4N8D

DPP4 complexed with syn-7aa

Summary for 4N8D

Entry DOI	10.2210/pdb4n8d/pdb
Related	4N8E 4a5s
Descriptor	Dipeptidyl peptidase 4, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	176446.92
Authors	Ostermann, N.,Zink, F.,Kroemer, M. (deposition date: 2013-10-17, release date: 2014-02-12, Last modification date: 2020-07-29)
Primary citation	Namoto, K.,Sirockin, F.,Ostermann, N.,Gessier, F.,Flohr, S.,Sedrani, R.,Gerhartz, B.,Trappe, J.,Hassiepen, U.,Duttaroy, A.,Ferreira, S.,Sutton, J.M.,Clark, D.E.,Fenton, G.,Beswick, M.,Baeschlin, D.K. Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. Bioorg.Med.Chem.Lett., 24:731-736, 2014 Cited by PubMed: 24439847 DOI: 10.1016/j.bmcl.2013.12.118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.65 Å)

Structure validation