4N8E
DPP4 complexed with compound 12a
Summary for 4N8E
Entry DOI | 10.2210/pdb4n8e/pdb |
Related | 4a5s 4N8D |
Descriptor | Dipeptidyl peptidase 4, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 176445.72 |
Authors | Ostermann, N.,Zink, F.,Kroemer, M. (deposition date: 2013-10-17, release date: 2014-02-12, Last modification date: 2020-07-29) |
Primary citation | Namoto, K.,Sirockin, F.,Ostermann, N.,Gessier, F.,Flohr, S.,Sedrani, R.,Gerhartz, B.,Trappe, J.,Hassiepen, U.,Duttaroy, A.,Ferreira, S.,Sutton, J.M.,Clark, D.E.,Fenton, G.,Beswick, M.,Baeschlin, D.K. Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV. Bioorg.Med.Chem.Lett., 24:731-736, 2014 Cited by PubMed: 24439847DOI: 10.1016/j.bmcl.2013.12.118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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