8GJX

Structure of the human STING receptor bound to 2'3'-cUA

Summary for 8GJX

Entry DOI	10.2210/pdb8gjx/pdb
Descriptor	Stimulator of interferon genes protein, 2'3'-cUA (3 entities in total)
Functional Keywords	sting, cyclic dinucleotide, innate immunity, cgas, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	43949.99
Authors	Morehouse, B.R.,Li, Y.,Slavik, K.M.,Toyoda, H.,Kranzusch, P.J. (deposition date: 2023-03-16, release date: 2023-07-05, Last modification date: 2023-08-02)
Primary citation	Li, Y.,Slavik, K.M.,Toyoda, H.C.,Morehouse, B.R.,de Oliveira Mann, C.C.,Elek, A.,Levy, S.,Wang, Z.,Mears, K.S.,Liu, J.,Kashin, D.,Guo, X.,Mass, T.,Sebe-Pedros, A.,Schwede, F.,Kranzusch, P.J. cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186:3261-3276.e20, 2023 Cited by PubMed: 37379839 DOI: 10.1016/j.cell.2023.05.038 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation