8GJX
Structure of the human STING receptor bound to 2'3'-cUA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Stimulator of interferon genes protein | polymer | 189 | 21657.3 | 2 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | C (B) | 2'3'-cUA | non-polymer | 635.4 | 1 | Chemie (ZNT) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A, B: 154 - 341 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Ser 153 | - | expression tag |
| Arg 232 | His 232 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43314.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 635.4 | |
| All* | Total formula weight | 43950.0 |
