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1FYN
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BU of 1fyn by Molmil
PHOSPHOTRANSFERASE
Descriptor: 3BP-2, PHOSPHOTRANSFERASE FYN
Authors:Musacchio, A, Saraste, M, Wilmanns, M.
Deposit date:1995-05-17
Release date:1996-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-resolution crystal structures of tyrosine kinase SH3 domains complexed with proline-rich peptides.
Nat.Struct.Biol., 1, 1994
5WRL
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BU of 5wrl by Molmil
Mu2 subunit of the clathrin adaptor complex AP2 in complex with IRS-1 Y628 peptide
Descriptor: AP-2 complex subunit mu, Insulin receptor substrate 1
Authors:Yoneyama, Y, Niwa, H, Umehara, T, Yokoyama, S, Hakuno, F, Takahashi, S.
Deposit date:2016-12-02
Release date:2017-12-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.095 Å)
Cite:IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
Elife, 7, 2018
7QSL
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BU of 7qsl by Molmil
Bovine complex I in lipid nanodisc, Active-apo
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ...
Authors:Chung, I, Bridges, H.R, Hirst, J.
Deposit date:2022-01-13
Release date:2022-05-25
Last modified:2022-09-28
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Cryo-EM structures define ubiquinone-10 binding to mitochondrial complex I and conformational transitions accompanying Q-site occupancy.
Nat Commun, 13, 2022
7Z3J
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BU of 7z3j by Molmil
Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ...
Authors:Pinotsis, N, Bunney, T.D, Katan, M.
Deposit date:2022-03-02
Release date:2022-07-20
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
Sci Adv, 8, 2022
6G46
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BU of 6g46 by Molmil
Red kidney bean purple acid phosphatase in complex with 2-(Naphthalen-1-yl)thiazole-4-carboxylic acid
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-naphthalen-1-yl-1,3-thiazole-4-carboxylic acid, ...
Authors:Feder, D.F.
Deposit date:2018-03-26
Release date:2018-09-26
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics.
Eur J Med Chem, 157, 2018
4OR7
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BU of 4or7 by Molmil
Klebsiella pneumoniae dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine
Descriptor: 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Lamb, K.M, Anderson, A.C.
Deposit date:2014-02-11
Release date:2014-12-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity.
Antimicrob.Agents Chemother., 58, 2014
5NX2
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BU of 5nx2 by Molmil
Crystal structure of thermostabilised full-length GLP-1R in complex with a truncated peptide agonist at 3.7 A resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glucagon-like peptide 1 receptor, ...
Authors:Rappas, M, Jazayeri, A, Brown, A.J.H, Kean, J, Errey, J.C, Robertson, N, Fiez-Vandal, C, Andrews, S.P, Congreve, M, Bortolato, A, Mason, J.S, Baig, A.H, Teobald, I, Dore, A.S, Weir, M, Cooke, R.M, Marshall, F.H.
Deposit date:2017-05-09
Release date:2017-06-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of the GLP-1 receptor bound to a peptide agonist.
Nature, 546, 2017
8AS0
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BU of 8as0 by Molmil
PD-1 extracellular domain in complex with Fab fragment from D12 antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Ongaro, T, Scietti, L, Pluss, L, Peissert, F, Villa, A, Puca, E, De Luca, R, Neri, D, Forneris, F.
Deposit date:2022-08-17
Release date:2022-11-23
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Selection of a PD-1 blocking antibody from a novel fully human phage display library.
Protein Sci., 31, 2022
3OGA
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BU of 3oga by Molmil
1.75 Angstrom resolution crystal structure of a putative NTP pyrophosphohydrolase (yfaO) from Salmonella typhimurium LT2
Descriptor: BETA-MERCAPTOETHANOL, Nucleoside triphosphatase nudI, PHOSPHATE ION
Authors:Halavaty, A.S, Minasov, G, Shuvalova, L, Winsor, J, Dubrovska, I, Peterson, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2010-08-16
Release date:2010-10-06
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:1.75 Angstrom resolution crystal structure of a putative NTP pyrophosphohydrolase (yfaO) from Salmonella typhimurium LT2
To be Published
5AEJ
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BU of 5aej by Molmil
Crystal structure of human Gremlin-1
Descriptor: GREMLIN-1, SULFATE ION
Authors:Kisonaite, M, Hyvonen, M.
Deposit date:2015-08-31
Release date:2016-04-13
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.904 Å)
Cite:Structure of Gremlin-1 and Analysis of its Interaction with Bmp-2.
Biochem.J., 473, 2016
5UD1
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BU of 5ud1 by Molmil
Class II fructose-1,6-bisphosphate aldolase H180Q variant of Helicobacter pylori
Descriptor: Fructose-bisphosphate aldolase, SODIUM ION, ZINC ION
Authors:Jacques, B, Sygusch, J.
Deposit date:2016-12-23
Release date:2018-04-11
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.795 Å)
Cite:Active site remodeling during the catalytic cycle in metal-dependent fructose-1,6-bisphosphate aldolases.
J. Biol. Chem., 293, 2018
6JBT
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BU of 6jbt by Molmil
Complex structure of toripalimab-Fab and PD-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain, ...
Authors:Guo, L, Tan, S, Chai, Y, Qi, J, Gao, G.F, Yan, J.
Deposit date:2019-01-26
Release date:2019-06-19
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.
Mabs, 11, 2019
3AK2
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BU of 3ak2 by Molmil
Superoxide dismutase from Aeropyrum pernix K1, Mn-bound form
Descriptor: 1,2-ETHANEDIOL, MANGANESE (II) ION, Superoxide dismutase [Mn/Fe]
Authors:Nakamura, T, Uegaki, K.
Deposit date:2010-06-30
Release date:2011-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal structure of the cambialistic superoxide dismutase from Aeropyrum pernix K1 - insights into the enzyme mechanism and stability
Febs J., 278, 2011
3E2C
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BU of 3e2c by Molmil
Escherichia coli Bacterioferritin Mutant E128R/E135R
Descriptor: 1,2-ETHANEDIOL, Bacterioferritin, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Wong, S.G, Tom-Yew, S.A.L, Lewin, A, Le Brun, N.E, Moore, G.R, Murphy, M.E.P, Mauk, A.G.
Deposit date:2008-08-05
Release date:2009-05-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Mechanistic Studies of a Stabilized Subunit Dimer Variant of Escherichia coli Bacterioferritin Identify Residues Required for Core Formation.
J.Biol.Chem., 284, 2009
5ZRU
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BU of 5zru by Molmil
Crystal structure of Agl-KA catalytic domain
Descriptor: 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, Alpha-1,3-glucanase, CALCIUM ION, ...
Authors:Yano, S, Makabe, K.
Deposit date:2018-04-25
Release date:2019-10-23
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.833 Å)
Cite:Crystal structure of the catalytic unit of GH 87-type alpha-1,3-glucanase Agl-KA from Bacillus circulans.
Sci Rep, 9, 2019
4DOY
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BU of 4doy by Molmil
Crystal structure of Dibenzothiophene desulfurization enzyme C
Descriptor: Dibenzothiophene desulfurization enzyme C, GLYCEROL
Authors:Liu, S, Zhang, C, Zhu, D, Gu, L.
Deposit date:2012-02-12
Release date:2013-02-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.789 Å)
Cite:Crystal structure of DszC from Rhodococcus sp. XP at 1.79 angstrom
Proteins, 82, 2014
4DFR
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BU of 4dfr by Molmil
CRYSTAL STRUCTURES OF ESCHERICHIA COLI AND LACTOBACILLUS CASEI DIHYDROFOLATE REDUCTASE REFINED AT 1.7 ANGSTROMS RESOLUTION. I. GENERAL FEATURES AND BINDING OF METHOTREXATE
Descriptor: CALCIUM ION, CHLORIDE ION, DIHYDROFOLATE REDUCTASE, ...
Authors:Filman, D.J, Matthews, D.A, Bolin, J.T, Kraut, J.
Deposit date:1982-06-25
Release date:1982-10-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of Escherichia coli and Lactobacillus casei dihydrofolate reductase refined at 1.7 A resolution. I. General features and binding of methotrexate.
J.Biol.Chem., 257, 1982
5DG8
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BU of 5dg8 by Molmil
CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dAMPNPP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION
Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(EDA)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
Authors:Patra, A, Egli, M.
Deposit date:2015-08-27
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291, 2016
6N1S
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BU of 6n1s by Molmil
Toxoplasma gondii TS-DHFR in complex with selective inhibitor 29
Descriptor: 1,2-ETHANEDIOL, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, ...
Authors:Hopper, A.T, Brockman, A, Wise, A, Gould, J, Barks, J, Radke, J.B, Sibley, L.D, Zou, Y, Thomas, S.B.
Deposit date:2018-11-11
Release date:2019-01-23
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of Selective Toxoplasma gondii Dihydrofolate Reductase Inhibitors for the Treatment of Toxoplasmosis.
J. Med. Chem., 62, 2019
5DG7
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BU of 5dg7 by Molmil
CRYSTAL STRUCTURE OF HUMAN DNA POLYMERASE ETA INSERTING dTTP ACROSS A DNA TEMPLATE CONTAINING 1,N6-ETHENODEOXYADENOSINE LESION
Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), DNA (5'-D(*CP*AP*TP*(EDA)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), ...
Authors:Patra, A, Egli, M.
Deposit date:2015-08-27
Release date:2016-06-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural and Kinetic Analysis of Miscoding Opposite the DNA Adduct 1,N6-Ethenodeoxyadenosine by Human Translesion DNA Polymerase eta.
J.Biol.Chem., 291, 2016
1O0S
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BU of 1o0s by Molmil
Crystal Structure of Ascaris suum Malic Enzyme Complexed with NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, NAD-dependent malic enzyme, TARTRONATE
Authors:Rao, G.S, Coleman, D.E, Karsten, W.E, Cook, P.F, Harris, B.G.
Deposit date:2003-02-24
Release date:2003-07-22
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic studies on Ascaris suum NAD-malic enzyme bound to reduced cofactor and identification of an effector site.
J.Biol.Chem., 278, 2003
1VRW
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BU of 1vrw by Molmil
Crystal structure analysis of plasmodium falciparum enoyl-acyl-carrier-protein reductase with nadh
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ENOYL-ACYL CARRIER REDUCTASE
Authors:Perozzo, R, Kuo, M, Sidhu, A.S, Valiyaveettil, J.T, Bittman, R, Jacobs Jr, W.R, Fidock, D.A, Sacchettini, J.C.
Deposit date:2005-06-30
Release date:2005-07-05
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Elucidation of the Specificity of the Antibacterial Agent Triclosan for Malarial Enoyl Acyl Carrier Protein Reductase
J.Biol.Chem., 277, 2002
1O02
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BU of 1o02 by Molmil
Human mitochondrial aldehyde dehydrogenase complexed with NADH in the presence of Mg2+
Descriptor: 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Aldehyde dehydrogenase, ...
Authors:Perez-Miller, S.J, Hurley, T.D.
Deposit date:2003-02-20
Release date:2003-06-24
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase
Biochemistry, 42, 2003
4NS3
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BU of 4ns3 by Molmil
Crystal structure of the Delta-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis bound with NAD and cobalamin
Descriptor: COBALAMIN, Delta-1-pyrroline-5-carboxylate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lagautriere, T, Bashiri, G, Baker, E.N.
Deposit date:2013-11-27
Release date:2015-01-14
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Use of a "silver bullet" to resolve crystal lattice dislocation disorder: A cobalamin complex of Delta (1)-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
J.Struct.Biol., 189, 2015
1OBF
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BU of 1obf by Molmil
The crystal structure of Glyceraldehyde 3-phosphate Dehydrogenase from Alcaligenes xylosoxidans at 1.7A resolution.
Descriptor: GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, POTASSIUM ION, SULFATE ION, ...
Authors:Antonyuk, S.V, Eady, R.R, Strange, R.W, Hasnain, S.S.
Deposit date:2003-01-30
Release date:2003-06-12
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The Structure of Glyceraldehyde 3-Phosphate Dehydrogenase from Alcaligenes Xylosoxidans at 1.7 A Resolution
Acta Crystallogr.,Sect.D, 59, 2003

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数据于2025-10-08公开中

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