6JBT

Complex structure of toripalimab-Fab and PD-1

Summary for 6JBT

• Entry DOI: 10.2210/pdb6jbt/pdb
• Descriptor: Programmed cell death protein 1, Heavy chain, Light chain, ... (6 entities in total)
• Functional Keywords: toripalimab-fab, pd-1, glycosylation, complex structure, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 67055.62

Authors

Guo, L.,Tan, S.,Chai, Y.,Qi, J.,Gao, G.F.,Yan, J. (deposition date: 2019-01-26, release date: 2019-06-19, Last modification date: 2023-11-22)

• Primary citation: Liu, H.,Guo, L.,Zhang, J.,Zhou, Y.,Zhou, J.,Yao, J.,Wu, H.,Yao, S.,Chen, B.,Chai, Y.,Qi, J.,Gao, G.F.,Tan, S.,Feng, H.,Yan, J.; Glycosylation-independent binding of monoclonal antibody toripalimab to FG loop of PD-1 for tumor immune checkpoint therapy.; Mabs, 11:681-690, 2019; PubMed: 30892132; DOI: 10.1080/19420862.2019.1596513

Experimental method

X-RAY DIFFRACTION (2.47 Å)