4OR7
Klebsiella pneumoniae dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine
Summary for 4OR7
Entry DOI | 10.2210/pdb4or7/pdb |
Related | 4OSG |
Descriptor | Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine, ... (4 entities in total) |
Functional Keywords | 5, 6, 7, 8-tetrahydrofolate; 7, 8-dihydrofolate, hydride shift, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Klebsiella pneumoniae CG43 |
Total number of polymer chains | 1 |
Total formula weight | 19886.94 |
Authors | Lamb, K.M.,Anderson, A.C. (deposition date: 2014-02-11, release date: 2014-12-03, Last modification date: 2024-02-28) |
Primary citation | Lamb, K.M.,Lombardo, M.N.,Alverson, J.,Priestley, N.D.,Wright, D.L.,Anderson, A.C. Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity. Antimicrob.Agents Chemother., 58:7484-7491, 2014 Cited by PubMed: 25288083DOI: 10.1128/AAC.03555-14 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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