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4OR7

Klebsiella pneumoniae dihydrofolate reductase complexed with NADPH and 6-ethyl-5-{3-[3-(pyrimidin-5-yl)phenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004146molecular_functiondihydrofolate reductase activity
A0046654biological_processtetrahydrofolate biosynthetic process
A0050661molecular_functionNADP binding
Functional Information from PDB Data
site_idAC1
Number of Residues37
DetailsBINDING SITE FOR RESIDUE NAP A 201
ChainResidue
AALA6
AGLY43
AARG44
ALEU45
ATHR46
AILE62
ASER63
ASER64
ASER76
AILE94
AGLY96
AALA7
AGLY97
AARG98
AVAL99
ATYR100
AGLN102
A25U202
AHOH305
AHOH313
AHOH326
AHOH327
AILE14
AHOH341
AHOH352
AHOH380
AHOH408
AHOH409
AHOH429
AHOH433
AHOH446
AGLY15
AMET16
AASN18
AALA19
AMET20
ATRP22

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE 25U A 202
ChainResidue
AILE5
AALA6
AMET20
AASP27
ALEU28
APHE31
ASER49
AILE50
AARG52
ALEU54
AILE94
ATYR100
ATHR113
ANAP201
AHOH301

Functional Information from PROSITE/UniProt
site_idPS00075
Number of Residues23
DetailsDHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT
ChainResidueDetails
AVAL13-THR35

226707

PDB entries from 2024-10-30

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