Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE NAP A 201 |
| Chain | Residue |
| A | ALA6 |
| A | GLY43 |
| A | ARG44 |
| A | LEU45 |
| A | THR46 |
| A | ILE62 |
| A | SER63 |
| A | SER64 |
| A | SER76 |
| A | ILE94 |
| A | GLY96 |
| A | ALA7 |
| A | GLY97 |
| A | ARG98 |
| A | VAL99 |
| A | TYR100 |
| A | GLN102 |
| A | 25U202 |
| A | HOH305 |
| A | HOH313 |
| A | HOH326 |
| A | HOH327 |
| A | ILE14 |
| A | HOH341 |
| A | HOH352 |
| A | HOH380 |
| A | HOH408 |
| A | HOH409 |
| A | HOH429 |
| A | HOH433 |
| A | HOH446 |
| A | GLY15 |
| A | MET16 |
| A | ASN18 |
| A | ALA19 |
| A | MET20 |
| A | TRP22 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 25U A 202 |
| Chain | Residue |
| A | ILE5 |
| A | ALA6 |
| A | MET20 |
| A | ASP27 |
| A | LEU28 |
| A | PHE31 |
| A | SER49 |
| A | ILE50 |
| A | ARG52 |
| A | LEU54 |
| A | ILE94 |
| A | TYR100 |
| A | THR113 |
| A | NAP201 |
| A | HOH301 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT |
| Chain | Residue | Details |
| A | VAL13-THR35 | |
