Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 37 |
Details | BINDING SITE FOR RESIDUE NAP A 201 |
Chain | Residue |
A | ALA6 |
A | GLY43 |
A | ARG44 |
A | LEU45 |
A | THR46 |
A | ILE62 |
A | SER63 |
A | SER64 |
A | SER76 |
A | ILE94 |
A | GLY96 |
A | ALA7 |
A | GLY97 |
A | ARG98 |
A | VAL99 |
A | TYR100 |
A | GLN102 |
A | 25U202 |
A | HOH305 |
A | HOH313 |
A | HOH326 |
A | HOH327 |
A | ILE14 |
A | HOH341 |
A | HOH352 |
A | HOH380 |
A | HOH408 |
A | HOH409 |
A | HOH429 |
A | HOH433 |
A | HOH446 |
A | GLY15 |
A | MET16 |
A | ASN18 |
A | ALA19 |
A | MET20 |
A | TRP22 |
site_id | AC2 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 25U A 202 |
Chain | Residue |
A | ILE5 |
A | ALA6 |
A | MET20 |
A | ASP27 |
A | LEU28 |
A | PHE31 |
A | SER49 |
A | ILE50 |
A | ARG52 |
A | LEU54 |
A | ILE94 |
A | TYR100 |
A | THR113 |
A | NAP201 |
A | HOH301 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT |
Chain | Residue | Details |
A | VAL13-THR35 | |