8AS0

PD-1 extracellular domain in complex with Fab fragment from D12 antibody

Summary for 8AS0

• Entry DOI: 10.2210/pdb8as0/pdb
• Descriptor: D12 antibody light chain, Fab fragment, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: monoclonal antibodies, phage display technology, antibody library, human pd-1, immunotherapy, antitumor protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 24
• Total formula weight: 539786.73

Authors

Ongaro, T.,Scietti, L.,Pluss, L.,Peissert, F.,Villa, A.,Puca, E.,De Luca, R.,Neri, D.,Forneris, F. (deposition date: 2022-08-17, release date: 2022-11-23, Last modification date: 2024-01-31)

• Primary citation: Peissert, F.,Pluss, L.,Giudice, A.M.,Ongaro, T.,Villa, A.,Elsayed, A.,Nadal, L.,Dakhel Plaza, S.,Scietti, L.,Puca, E.,De Luca, R.,Forneris, F.,Neri, D.; Selection of a PD-1 blocking antibody from a novel fully human phage display library.; Protein Sci., 31:e4486-e4486, 2022; PubMed: 36317676; DOI: 10.1002/pro.4486

Experimental method

X-RAY DIFFRACTION (3.5 Å)