8AS0
PD-1 extracellular domain in complex with Fab fragment from D12 antibody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016020 | cellular_component | membrane |
| A | 0050777 | biological_process | negative regulation of immune response |
| F | 0016020 | cellular_component | membrane |
| F | 0050777 | biological_process | negative regulation of immune response |
| I | 0016020 | cellular_component | membrane |
| I | 0050777 | biological_process | negative regulation of immune response |
| L | 0016020 | cellular_component | membrane |
| L | 0050777 | biological_process | negative regulation of immune response |
| O | 0016020 | cellular_component | membrane |
| O | 0050777 | biological_process | negative regulation of immune response |
| R | 0016020 | cellular_component | membrane |
| R | 0050777 | biological_process | negative regulation of immune response |
| X | 0016020 | cellular_component | membrane |
| X | 0050777 | biological_process | negative regulation of immune response |
| Y | 0016020 | cellular_component | membrane |
| Y | 0050777 | biological_process | negative regulation of immune response |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| C | TYR192-HIS198 | |
| B | TYR199-HIS205 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 56 |
| Details | Region: {"description":"Interaction with CD274/PDCD1L1","evidences":[{"source":"PubMed","id":"26602187","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28165004","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WT9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 440 |
| Details | Domain: {"description":"Ig-like V-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 100 |
| Details | Region: {"description":"Pembrolizumab binding","evidences":[{"source":"PubMed","id":"27325296","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27734966","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5B8C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JXE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
